{"id":"lutein","rwe":[],"_fda":{"id":"30c8e7e7-7cba-c12f-e063-6394a90a41e9","set_id":"b9b71fa4-89c7-4f5b-8174-950649434ba5","openfda":{"nui":["N0000193618","M0001797","M0022797","N0000175952","N0000185508","N0000175629","N0000184306","M0000728","M0022794","N0000175951","M0022788","N0000175950"],"upc":["0306420207907"],"unii":["LU4B53JYVE","73Y7P0K73Y","PQ6CK8PD0R","6SO6U10H04","568ET80C3D","1C6V77QF41","0R0008Q3JB","LRX7AJ16DT","P6YC3EG204","935E97BOY8","X72A60C9MT","3A3U0GI71G","42Z2K6ZL8P","25X51I8RD4","68Y4CF58BV","TLM2976OFR","H6241UJ22B","X66NSO3N35","81G40H8B0T","SOI2LOH54Z"],"route":["ORAL"],"spl_id":["30c8e7e7-7cba-c12f-e063-6394a90a41e9"],"brand_name":["Strovite One Caplets"],"spl_set_id":["b9b71fa4-89c7-4f5b-8174-950649434ba5"],"package_ndc":["0642-0207-90","0642-0207-03"],"product_ndc":["0642-0207"],"generic_name":["VITAMIN A, CALCIUM PANTOTHENATE, ASCORBIC ACID, CHOLECALCIFEROL, .ALPHA.-TOCOPHEROL SUCCINATE, D-, THIAMINE, RIBOFLAVIN, NIACINAMIDE, PYRIDOXINE HYDROCHLORIDE, FOLIC ACID, BIOTIN, CYANOCOBALAMIN, SELENIUM, MAGNESIUM OXIDE, ZINC OXIDE, CUPRIC SULFATE, MANGANESE, CHROMIUM, .ALPHA.-LIPOIC ACID, AND LUTEIN"],"product_type":["HUMAN PRESCRIPTION DRUG"],"pharm_class_cs":["Ascorbic Acid [CS]","Vitamin D [CS]","Allergens [CS]","Vitamin B 12 [CS]","Vitamin A [CS]"],"pharm_class_pe":["Increased Histamine Release [PE]","Cell-mediated Immunity [PE]"],"substance_name":[".ALPHA.-TOCOPHEROL SUCCINATE, D-","ALPHA LIPOIC ACID","ASCORBIC ACID","BIOTIN","CALCIUM PANTOTHENATE","CHOLECALCIFEROL","CHROMIUM","CUPRIC SULFATE","CYANOCOBALAMIN","FOLIC ACID","LUTEIN","MAGNESIUM OXIDE","MANGANESE","NIACINAMIDE","PYRIDOXINE HYDROCHLORIDE","RIBOFLAVIN","SELENIUM","THIAMINE","VITAMIN A","ZINC OXIDE"],"pharm_class_epc":["Vitamin C [EPC]","Vitamin D [EPC]","Standardized Chemical Allergen [EPC]","Vitamin B12 [EPC]","Vitamin A [EPC]"],"manufacturer_name":["Exeltis USA, Inc."],"is_original_packager":[true]},"version":"5","description":["COMPOSITION Each caplet contains: Vitamin A (as beta carotene) 900 mcg RAE Vitamin C 300 mg Vitamin D (as cholecalciferol) 25 mcg Vitamin E (as d-alpha tocopheryl succinate) 67 mg Thiamin (as thiamine hydrochloride) 20 mg Riboflavin (vitamin B2) 5 mg Niacin (as niacinamide) 25 mg NE Vitamin B6 (as pyridoxine hydrochloride) 25 mg Folate (as folic acid) 1,670 mcg DFE Vitamin B12 (as cyanocobalamin) 50 mcg Biotin 100 mcg Pantothenic Acid (as calcium-D-pantothenate) 15 mg Magnesium (as magnesium oxide) 50 mg Zinc (as zinc oxide) 25 mg Selenium (as sodium selenate) 100 mcg Copper (as cupric sulfate) 1.5 mg Manganese (as manganese sulfate) 1.5 mg Chromium (as chromium chloride) 50 mcg Alpha Lipoic Acid 7.5 mg Lutein 5 mg Other ingredients: Microcrystalline cellulose, dicalcium phosphate, hydroxypropyl methylcellulose, croscarmellose sodium, polyethylene glycol, titanium dioxide, talc, maltodextrin, modified food starch, sucrose, polyvinyl alcohol, stearic acid, silica, magnesium stearate, corn oil, starch, vitamin E alcohol, sodium ascorbate, mannitol."],"precautions":["Drug Interactions High doses of folic acid may result in decreased serum levels of anticonvulsant drugs. Vitamin D supplementation should not be given with large amounts of calcium in those with hypercalcemia or conditions that may lead to hyper-calcemia such as hyperparathyroidism and those who form calcium-containing kidney stones. Zinc can inhibit the absorption of certain antibiotics; take at least 2 hours apart to minimize interactions. Consult appropriate references for additional specific vitamin-drug interactions. Information for Patients Patients should be counseled to disclose all medical conditions, including use of all medications, vitamins and supplements, pregnancy, and breastfeeding. Pediatric Use Not recommended for pediatric use."],"how_supplied":["HOW SUPPLIED STROVITE ® ONE is a white, oblong caplet, debossed EV0207; available in bottles of 90 caplets (0642-0207-90) and as professional samples (0642-0207-03). Storage conditions: Store at room temperature 15°-30°C (59°-86°F). Avoid excessive heat and moisture."],"pediatric_use":["Pediatric Use Not recommended for pediatric use."],"effective_time":"20250320","adverse_reactions":["ADVERSE REACTIONS Adverse reactions have been reported with specific vitamins and minerals, but generally at levels substantially higher than those in STROVITE ® ONE."],"contraindications":["CONTRAINDICATIONS STROVITE ® ONE is contraindicated in patients with hypersensitivity to any of its components. Folic Acid is contraindicated in patients with untreated and uncomplicated pernicious anemia, and in those with anaphylactic sensitivity to folic acid. Cyanocobalamin is contraindicated in patients with sensitivity to cobalt or to cyanocobalamin (Vitamin B12)."],"description_table":["<table width=\"60%\" styleCode=\"Noautorules\"><colgroup><col align=\"left\" valign=\"top\" width=\"76%\"/><col align=\"left\" valign=\"top\" width=\"3%\"/><col align=\"left\" valign=\"top\" width=\"21%\"/></colgroup><tbody><tr><td colspan=\"3\"><content styleCode=\"bold\">Each caplet contains:</content></td></tr><tr><td>Vitamin A (as beta carotene)</td><td/><td>900 mcg RAE</td></tr><tr><td>Vitamin C </td><td/><td>300 mg</td></tr><tr><td>Vitamin D (as cholecalciferol)</td><td/><td>25 mcg</td></tr><tr><td>Vitamin E (as d-alpha tocopheryl succinate)</td><td/><td>67 mg</td></tr><tr><td>Thiamin (as thiamine hydrochloride)</td><td/><td>20 mg</td></tr><tr><td>Riboflavin (vitamin B2)</td><td/><td>5 mg</td></tr><tr><td>Niacin (as niacinamide)</td><td/><td>25 mg NE</td></tr><tr><td>Vitamin B6 (as pyridoxine hydrochloride)</td><td/><td>25 mg</td></tr><tr><td>Folate (as folic acid)</td><td/><td>1,670 mcg DFE</td></tr><tr><td>Vitamin B12 (as cyanocobalamin)</td><td/><td>50 mcg</td></tr><tr><td>Biotin</td><td/><td>100 mcg</td></tr><tr><td>Pantothenic Acid (as calcium-D-pantothenate)</td><td/><td>15 mg</td></tr><tr><td>Magnesium (as magnesium oxide)</td><td/><td>50 mg</td></tr><tr><td>Zinc (as zinc oxide)</td><td/><td>25 mg</td></tr><tr><td>Selenium (as sodium selenate)</td><td/><td>100 mcg</td></tr><tr><td>Copper (as cupric sulfate)</td><td/><td>1.5 mg</td></tr><tr><td>Manganese (as manganese sulfate)</td><td/><td>1.5 mg</td></tr><tr><td>Chromium (as chromium chloride)</td><td/><td>50 mcg</td></tr><tr><td>Alpha Lipoic Acid</td><td/><td>7.5 mg</td></tr><tr><td>Lutein</td><td/><td>5 mg</td></tr></tbody></table>"],"drug_interactions":["Drug Interactions High doses of folic acid may result in decreased serum levels of anticonvulsant drugs. Vitamin D supplementation should not be given with large amounts of calcium in those with hypercalcemia or conditions that may lead to hyper-calcemia such as hyperparathyroidism and those who form calcium-containing kidney stones. Zinc can inhibit the absorption of certain antibiotics; take at least 2 hours apart to minimize interactions. Consult appropriate references for additional specific vitamin-drug interactions."],"storage_and_handling":["Storage conditions: Store at room temperature 15°-30°C (59°-86°F). Avoid excessive heat and moisture."],"indications_and_usage":["INDICATIONS AND USAGE STROVITE ® ONE is indicated to provide nutritional supplementation to support optimum vitamin and mineral levels."],"warnings_and_cautions":["WARNING/PRECAUTIONS Vitamin D supplementation should be used with caution in those with hypercalcemia or conditions that may lead to hypercalcemia such as hyperparathyroidism and those who form calcium-containing kidney stones. High doses of vitamin D can lead to elevated levels of calcium that reside in the blood and soft tissues. Bone pain, high blood pressure, formation of kidney stones, renal failure, and increased risk of heart disease can occur. Folic acid, especially in doses above 0.1 mg daily, may obscure pernicious anemia, in that hematologic remission may occur while neurological manifestations remain progressive. The use of folic acid doses above 1 mg daily may precipitate or exacerbate the neurological damage of vitamin B12 deficiency. Avoid overdosage. Keep out of the reach of children."],"information_for_patients":["Information for Patients Patients should be counseled to disclose all medical conditions, including use of all medications, vitamins and supplements, pregnancy, and breastfeeding."],"spl_unclassified_section":["0642-0207-90 STROVITE ® ONE IRON FREE MULTIVITAMIN AND MINERAL SUPPLEMENT Rx","KEEP OUT OF REACH OF CHILDREN. Rx MANUFACTURED IN THE USA Distributed by: Exeltis USA, Inc. Florham Park, NJ 07932 1-877-324-9349 www.exeltisusa.com ©2022 Exeltis USA, Inc. All rights reserved. US PATENT NO. 6,863,904 STROVITE ® ONE is a trademark of Exeltis Healthcare S.L. Rev. 10/2022 2079003-04"],"dosage_and_administration":["DOSAGE AND ADMINISTRATION One caplet daily or as directed by a physician."],"spl_product_data_elements":["Strovite One Caplets Vitamin A, Calcium Pantothenate, Ascorbic Acid, Cholecalciferol, .Alpha.-Tocopherol Succinate, D-, Thiamine, Riboflavin, Niacinamide, Pyridoxine Hydrochloride, Folic Acid, Biotin, Cyanocobalamin, Selenium, Magnesium Oxide, Zinc Oxide, Cupric Sulfate, Manganese, Chromium, .Alpha.-Lipoic Acid, and Lutein HYDROXYPROPYL METHYLCELLULOSE MALTODEXTRIN STEARIC ACID MANNITOL MANGANESE MANGANESE CROSCARMELLOSE SODIUM MICROCRYSTALLINE CELLULOSE SILICON DIOXIDE TITANIUM DIOXIDE MAGNESIUM STEARATE POLYVINYL ALCOHOL, UNSPECIFIED STARCH, CORN TALC SUCROSE POLYETHYLENE GLYCOL, UNSPECIFIED ANHYDROUS DIBASIC CALCIUM PHOSPHATE TOCOPHEROL SODIUM ASCORBATE .ALPHA.-TOCOPHEROL, DL- VITAMIN A VITAMIN A CALCIUM PANTOTHENATE PANTOTHENIC ACID CALCIUM CATION ASCORBIC ACID ASCORBIC ACID CHOLECALCIFEROL CHOLECALCIFEROL .ALPHA.-TOCOPHEROL SUCCINATE, D- .ALPHA.-TOCOPHEROL, D- THIAMINE THIAMINE ION RIBOFLAVIN RIBOFLAVIN NIACINAMIDE NIACINAMIDE PYRIDOXINE HYDROCHLORIDE PYRIDOXINE FOLIC ACID FOLIC ACID BIOTIN BIOTIN CYANOCOBALAMIN CYANOCOBALAMIN SELENIUM SELENIUM MAGNESIUM OXIDE MAGNESIUM CATION ZINC OXIDE ZINC OXIDE CUPRIC SULFATE CUPRIC CATION CHROMIUM CHROMIUM ALPHA LIPOIC ACID ALPHA LIPOIC ACID LUTEIN LUTEIN MODIFIED CORN STARCH (1-OCTENYL SUCCINIC ANHYDRIDE) CORN OIL EV0207"],"package_label_principal_display_panel":["PRINCIPAL DISPLAY PANEL - 90 Caplet Bottle Label 0642-0207-90 Strovite ® ONE IRON FREE MULTIVITAMIN AND MINERAL SUPPLEMENT GLUTEN AND LACTOSE FREE 90 Caplets Rx Strovite One Bottle Label"]},"tags":[{"label":"lutein","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Oral","category":"route"},{"label":"Capsule","category":"form"},{"label":"Gum","category":"form"},{"label":"Powder","category":"form"},{"label":"Tablet","category":"form"},{"label":"Active","category":"status"},{"label":"Age related macular degeneration","category":"indication"},{"label":"Meibomian gland dysfunction","category":"indication"},{"label":"Tear film insufficiency","category":"indication"}],"phase":"marketed","safety":{"boxedWarnings":[],"safetySignals":[{"llr":131.186,"date":"","count":39,"signal":"Appendicolith","source":"DrugCentral FAERS","actionTaken":"Reported 39 times (LLR=131)"},{"llr":113.469,"date":"","count":37,"signal":"Blood phosphorus increased","source":"DrugCentral FAERS","actionTaken":"Reported 37 times (LLR=113)"},{"llr":96.225,"date":"","count":40,"signal":"Appendicitis","source":"DrugCentral FAERS","actionTaken":"Reported 40 times (LLR=96)"},{"llr":84.275,"date":"","count":41,"signal":"Ventricular fibrillation","source":"DrugCentral FAERS","actionTaken":"Reported 41 times (LLR=84)"},{"llr":69.328,"date":"","count":39,"signal":"Cardiogenic shock","source":"DrugCentral FAERS","actionTaken":"Reported 39 times (LLR=69)"},{"llr":64.601,"date":"","count":50,"signal":"Stress","source":"DrugCentral FAERS","actionTaken":"Reported 50 times (LLR=65)"},{"llr":58.269,"date":"","count":23,"signal":"Myasthenia gravis","source":"DrugCentral FAERS","actionTaken":"Reported 23 times (LLR=58)"},{"llr":55.514,"date":"","count":24,"signal":"Blood uric acid increased","source":"DrugCentral FAERS","actionTaken":"Reported 24 times (LLR=56)"},{"llr":51.187,"date":"","count":52,"signal":"Abdominal distension","source":"DrugCentral FAERS","actionTaken":"Reported 52 times (LLR=51)"},{"llr":48.906,"date":"","count":45,"signal":"Dry mouth","source":"DrugCentral FAERS","actionTaken":"Reported 45 times (LLR=49)"},{"llr":46.399,"date":"","count":40,"signal":"Ascites","source":"DrugCentral FAERS","actionTaken":"Reported 40 times (LLR=46)"},{"llr":38.672,"date":"","count":73,"signal":"Constipation","source":"DrugCentral FAERS","actionTaken":"Reported 73 times (LLR=39)"},{"llr":33.754,"date":"","count":21,"signal":"Macular degeneration","source":"DrugCentral FAERS","actionTaken":"Reported 21 times (LLR=34)"},{"llr":32.632,"date":"","count":48,"signal":"Hyponatraemia","source":"DrugCentral FAERS","actionTaken":"Reported 48 times (LLR=33)"},{"llr":31.495,"date":"","count":39,"signal":"Multiple organ dysfunction syndrome","source":"DrugCentral FAERS","actionTaken":"Reported 39 times (LLR=31)"}],"commonSideEffects":[{"effect":"Appendicolith","drugRate":"","severity":"common","_validated":false,"_confidence":0.3},{"effect":"Blood phosphorus increased","drugRate":"","severity":"common","_validated":false,"_confidence":0.3},{"effect":"Appendicitis","drugRate":"","severity":"common","_validated":false,"_confidence":0.3},{"effect":"Ventricular fibrillation","drugRate":"","severity":"common","_validated":false,"_confidence":0.3},{"effect":"Cardiogenic shock","drugRate":"","severity":"common","_validated":false,"_confidence":0.3},{"effect":"Stress","drugRate":"","severity":"common","_validated":false,"_confidence":0.3},{"effect":"Myasthenia gravis","drugRate":"","severity":"common","_validated":false,"_confidence":0.3},{"effect":"Blood uric acid increased","drugRate":"","severity":"common","_validated":false,"_confidence":0.3},{"effect":"Abdominal distension","drugRate":"","severity":"common","_validated":false,"_confidence":0.3},{"effect":"Dry mouth","drugRate":"","severity":"common","_validated":false,"_confidence":0.3},{"effect":"Ascites","drugRate":"","severity":"common","_validated":false,"_confidence":0.3},{"effect":"Constipation","drugRate":"","severity":"common","_validated":false,"_confidence":0.3},{"effect":"Macular degeneration","drugRate":"","severity":"common","_validated":false,"_confidence":0.3},{"effect":"Hyponatraemia","drugRate":"","severity":"common","_validated":false,"_confidence":0.3},{"effect":"Multiple organ dysfunction syndrome","drugRate":"","severity":"common","_validated":false,"_confidence":0.3}]},"trials":[],"aliases":[],"patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=LUTEIN","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T01:57:16.742745+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T01:57:23.013975+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=LUTEIN","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T01:57:23.450083+00:00"},"mechanism.drugClass":{"url":"https://api.fda.gov/drug/label.json","method":"deterministic","source":"FDA Label (EPC)","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T01:57:15.633528+00:00"},"administration.route":{"url":"","method":"deterministic","source":"FDA Label","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T01:57:15.633552+00:00"},"safety.boxedWarnings":{"url":"","method":"deterministic","source":"FDA Label (no boxed warning)","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T01:57:15.633558+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL173929/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T01:57:24.207268+00:00"}},"allNames":"xanthophyll","offLabel":[],"synonyms":["lutein","xanthophyll"],"timeline":[],"approvals":[{"date":"","orphan":false,"company":"","regulator":"FDA"}],"brandName":"Xanthophyll","ecosystem":[{"indication":"Age related macular degeneration","otherDrugs":[{"name":"ranibizumab","slug":"ranibizumab","company":"Genentech"}],"globalPrevalence":null},{"indication":"Meibomian gland dysfunction","otherDrugs":[],"globalPrevalence":null},{"indication":"Tear film insufficiency","otherDrugs":[{"name":"ciclosporin","slug":"ciclosporin","company":"Novartis"},{"name":"crospovidone","slug":"crospovidone","company":""},{"name":"lifitegrast","slug":"lifitegrast","company":"Shire Dev Llc"},{"name":"macrogol","slug":"macrogol","company":"Braintree"}],"globalPrevalence":null}],"mechanism":{"modality":"Small Molecule","drugClass":"Vitamin C [EPC]","explanation":"","oneSentence":"","technicalDetail":"Lutein is a carotenoid pigment that is selectively absorbed by the macula, where it quenches singlet oxygen and reduces the formation of reactive oxygen species, thereby protecting the retina from oxidative damage."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4145","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=LUTEIN","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=LUTEIN","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T12:27:07.407153","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T01:57:27.473413+00:00","fieldsConflicting":16,"overallConfidence":0.8},"biosimilars":[],"competitors":[],"genericName":"lutein","indications":{"approved":[{"name":"Age related macular degeneration","source":"DrugCentral","snomedId":267718000,"regulator":"FDA"},{"name":"Meibomian gland dysfunction","source":"DrugCentral","snomedId":397549002,"regulator":"FDA","eligibility":"not specified"},{"name":"Tear film insufficiency","source":"DrugCentral","snomedId":46152009,"regulator":"FDA","eligibility":"not specified"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT07420361","phase":"","title":"Lutein Iontophoresis in Intermediate AMD and Reticular Pseudodrusen - a Retrospective Study","status":"COMPLETED","sponsor":"Mario Damiano Toro","startDate":"2023-08-01","conditions":["Intermediate Age-Related Macular Degeneration With Reticular Pseudodrusen"],"enrollment":30,"completionDate":"2024-08-31"},{"nctId":"NCT07380438","phase":"NA","title":"A Clinical Study to Evaluate the Efficacy of a Nutritional Supplement to Improve Carotenoid Content as Measured by a Non-invasive Hyperspectral Absorption Device","status":"COMPLETED","sponsor":"Pharmanex","startDate":"2025-10-20","conditions":["Nutrition Assessment"],"enrollment":84,"completionDate":"2026-01-08"},{"nctId":"NCT06098677","phase":"NA","title":"Effect of Carotenoids Supplementation on Visual Function in Chinese Subjects","status":"NOT_YET_RECRUITING","sponsor":"Zhongshan Ophthalmic Center, Sun Yat-sen University","startDate":"2026-05-01","conditions":["Vision Disorders"],"enrollment":220,"completionDate":"2027-12-31"},{"nctId":"NCT06892444","phase":"NA","title":"Sweet Corn and Carotenoids","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Florida","startDate":"2025-05-14","conditions":["Carotenoids"],"enrollment":40,"completionDate":"2026-12-31"},{"nctId":"NCT07355725","phase":"NA","title":"To Evaluate the Efficacy of Lutemax 2020 on Vision and Cognitive Performance in Health Children.","status":"COMPLETED","sponsor":"Bioagile Therapeutics Pvt. Ltd.","startDate":"2022-07-21","conditions":["Cognitive"],"enrollment":60,"completionDate":"2023-01-27"},{"nctId":"NCT06158659","phase":"NA","title":"Improved Immunology Outcomes Associated With Lactoferrin Fortified With HMO in Infant Formula","status":"COMPLETED","sponsor":"Heilongjiang Feihe Dairy Co. Ltd.","startDate":"2023-11-14","conditions":["Flu","Cold"],"enrollment":240,"completionDate":"2025-04-03"},{"nctId":"NCT06159088","phase":"NA","title":"Improved Gut Health Outcomes Associated With Probiotics Fortified With Hydrolyzed Whey Protein in Infant Formula","status":"COMPLETED","sponsor":"Heilongjiang Feihe Dairy Co. Ltd.","startDate":"2023-11-14","conditions":["Gut Health","Gastrointestinal Diseases"],"enrollment":240,"completionDate":"2025-04-03"},{"nctId":"NCT06146387","phase":"NA","title":"Improved Cognitive Outcomes Associated With Feihe HMO With DHA/ARA in Infant Formula","status":"COMPLETED","sponsor":"Heilongjiang Feihe Dairy Co. Ltd.","startDate":"2023-11-14","conditions":["Cognitive Change"],"enrollment":240,"completionDate":"2025-04-03"},{"nctId":"NCT05208879","phase":"","title":"CArotenoid in hypoChOlesterolemia","status":"COMPLETED","sponsor":"Hospices Civils de Lyon","startDate":"2022-06-30","conditions":["Primary Intestinal Hypocholesterolemia","Abetalipoproteinemia","Chylomicron Retention Disease"],"enrollment":10,"completionDate":"2024-11-07"},{"nctId":"NCT04499820","phase":"NA","title":"Effect of OMEGA3 Supplementation in Diabetic Retinopathy","status":"COMPLETED","sponsor":"Centre Hospitalier Intercommunal Creteil","startDate":"2020-06-26","conditions":["Diabetic Retinopathy"],"enrollment":60,"completionDate":"2025-04-17"},{"nctId":"NCT02100774","phase":"","title":"Effect of Genetic Variants on Fat-soluble Vitamin Bioavailability","status":"COMPLETED","sponsor":"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement","startDate":"2009-01","conditions":["Biological Availability of Vitamins and Micronutrients"],"enrollment":45,"completionDate":"2013-12"},{"nctId":"NCT06489873","phase":"NA","title":"Lutein, Zeaxathin, and Fish Oil Supplementation","status":"RECRUITING","sponsor":"Texas A&M University","startDate":"2024-02-07","conditions":["Cognitive Performance","Age-Related Macular Degeneration","Bone Loss"],"enrollment":80,"completionDate":"2026-05-01"},{"nctId":"NCT06465888","phase":"NA","title":"Influence of Eggs on Cognitive Performance","status":"COMPLETED","sponsor":"Texas A&M University","startDate":"2017-08-22","conditions":["Cognitive Function"],"enrollment":106,"completionDate":"2020-03-19"},{"nctId":"NCT06965426","phase":"NA","title":"Effect of Lutein, Zeaxanthin, and Meso-Zeaxanthin Supplementation on Skin Carotenoid Concentration: A Six-Month, Placebo-Controlled Crossover Study","status":"RECRUITING","sponsor":"Insight Eyecare Specialties, Inc. dba Vision Source Eyecare,","startDate":"2025-06-01","conditions":["Macular Degenerative Disease"],"enrollment":60,"completionDate":"2026-12-01"},{"nctId":"NCT06237127","phase":"NA","title":"Effects of Goji vs. Fiber on Macular Degeneration","status":"RECRUITING","sponsor":"University of California, Davis","startDate":"2024-04-29","conditions":["Age-Related Macular Degeneration"],"enrollment":60,"completionDate":"2027-06-30"},{"nctId":"NCT07011602","phase":"NA","title":"INTEGRATED CHILDHOOD ACTIVITY AND NUTRITION (ICAN) STUDY","status":"RECRUITING","sponsor":"University of Illinois at Urbana-Champaign","startDate":"2025-06-04","conditions":["Achievement","Weight Change","Cognition","Fitness","Nutrition Status"],"enrollment":100,"completionDate":"2027-07-31"},{"nctId":"NCT06738446","phase":"NA","title":"Dietary Supplementation on Tear Secretion and Inflammation in DES","status":"COMPLETED","sponsor":"Shih Chien Huang","startDate":"2021-09-27","conditions":["Dry Eye Syndrome (DES)"],"enrollment":52,"completionDate":"2022-06-14"},{"nctId":"NCT06925893","phase":"","title":"Lutein by Scleral Iontophoresis in AMD","status":"RECRUITING","sponsor":"Federico II University","startDate":"2024-11-01","conditions":["Stage 3 AMD"],"enrollment":80,"completionDate":"2025-12-01"},{"nctId":"NCT06270680","phase":"EARLY_PHASE1","title":"Carotenoids for Collision Athletes","status":"COMPLETED","sponsor":"Penn State University","startDate":"2024-08-01","conditions":["Head Injury","Carotenoids"],"enrollment":31,"completionDate":"2024-11-22"},{"nctId":"NCT03838536","phase":"NA","title":"Synergistic Activity of Human Milk Nutrients and Infant Cognition","status":"RECRUITING","sponsor":"University of North Carolina, Chapel Hill","startDate":"2019-02-05","conditions":["Breastfeeding, Exclusive"],"enrollment":84,"completionDate":"2026-03"},{"nctId":"NCT06848101","phase":"NA","title":"Eye and Carotenoid Augmentation Research and Evaluation (EyeCARE)","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Illinois at Urbana-Champaign","startDate":"2024-03-15","conditions":["Vision","Eye Health"],"enrollment":40,"completionDate":"2025-03-14"},{"nctId":"NCT06749808","phase":"NA","title":"A Study to Assess the Impact of a Nutritional Supplement on Wellbeing and Nutrient Absorption","status":"ENROLLING_BY_INVITATION","sponsor":"Pharmanex","startDate":"2024-12-01","conditions":["Nutrition Status"],"enrollment":36,"completionDate":"2025-02"},{"nctId":"NCT05295030","phase":"NA","title":"Effects of Breast Milk Simulated Infant Formula","status":"COMPLETED","sponsor":"Sun Yat-sen University","startDate":"2022-04-10","conditions":["Infant Formula","Breast Milk"],"enrollment":179,"completionDate":"2023-12-25"},{"nctId":"NCT06686004","phase":"NA","title":"Bioavailability Trial","status":"COMPLETED","sponsor":"Newcastle University","startDate":"2022-08-01","conditions":["Absorption, Metabolism and Excretion in Healthy Volunteers","Bioavailability and AUC"],"enrollment":8,"completionDate":"2024-09-30"},{"nctId":"NCT04983017","phase":"NA","title":"2021 PMT iAge® Intervention Trial by Edifice Health","status":"TERMINATED","sponsor":"Edifice Health","startDate":"2021-08-10","conditions":["Chronic Inflammation","Inflammaging"],"enrollment":781,"completionDate":"2022-09-09"},{"nctId":"NCT06574685","phase":"NA","title":"Efficacy of Twinkle Eyez Supplementation in Improving Ocular Health and Immunity","status":"COMPLETED","sponsor":"Ecolite Group","startDate":"2024-07-01","conditions":["Dry Eye Disease","Immunity"],"enrollment":110,"completionDate":"2024-07-31"},{"nctId":"NCT06391411","phase":"NA","title":"Effect of Micronutrient Supplementation on the Intestinal Microbiota in Patients With Age-related Macular Degeneration - The Gut-Retina-axis Study","status":"COMPLETED","sponsor":"Azienda Ospedaliero-Universitaria Careggi","startDate":"2021-03-01","conditions":["Age-Related Macular Degeneration"],"enrollment":45,"completionDate":"2024-05-01"},{"nctId":"NCT06465342","phase":"","title":"LUTEIN BY SCLERAL IONTOPHORESIS IN PATIENTS WITH STAGE 3 AGE-RELATED MACULAR DEGENERATION (AMD)","status":"NOT_YET_RECRUITING","sponsor":"OFFHEALTH S.p.A.","startDate":"2024-06-12","conditions":["DML Stage 3"],"enrollment":80,"completionDate":"2025-12-12"},{"nctId":"NCT06358352","phase":"NA","title":"Clinical and Radiographic Assessment of PRF Versus Lutein Placement","status":"COMPLETED","sponsor":"Mansoura University","startDate":"2021-10-01","conditions":["Osteogenesis"],"enrollment":30,"completionDate":"2023-05-01"},{"nctId":"NCT05267522","phase":"NA","title":"Independent Effects of High-cholesterol (High-egg) and High-saturated Fat Diets on LDL-cholesterol","status":"COMPLETED","sponsor":"University of South Australia","startDate":"2022-03-01","conditions":["Hypercholesterolemia","Hyperlipidemias","Physical Inactivity","Diet, Healthy"],"enrollment":77,"completionDate":"2023-08-31"},{"nctId":"NCT05314647","phase":"NA","title":"Lutein Supplementation in Healthy Children","status":"UNKNOWN","sponsor":"Northcentral University","startDate":"2023-07-15","conditions":["Eye Fatigue","Diet, Healthy","Cognitive Change"],"enrollment":59,"completionDate":"2024-05"},{"nctId":"NCT04496817","phase":"NA","title":"Enriched Eggs for Retina Health in Type 2 Diabetes","status":"UNKNOWN","sponsor":"University of Manitoba","startDate":"2022-07-11","conditions":["Diabetic Retinopathy","Type 2 Diabetes"],"enrollment":60,"completionDate":"2024-09-01"},{"nctId":"NCT01789866","phase":"","title":"DHA & Lutein and fMRI Brain Mapping in Healthy Children","status":"COMPLETED","sponsor":"University of British Columbia","startDate":"2012-09","conditions":["Healthy Nutrition"],"enrollment":62,"completionDate":"2015-01"},{"nctId":"NCT03750968","phase":"PHASE2","title":"Lutein & Zeaxanthin in Pregnancy - Carotenoid Supplementation During Pregnancy: Ocular and Systemic Effects","status":"COMPLETED","sponsor":"Paul S. Bernstein","startDate":"2019-09-26","conditions":["Nutrient Deficiency","Pregnancy Related"],"enrollment":47,"completionDate":"2022-01-31"},{"nctId":"NCT05533658","phase":"NA","title":"The Effects of VisionPure™ on Indices of Vision Health and Cognitive Function","status":"COMPLETED","sponsor":"Applied Science & Performance Institute","startDate":"2022-08-01","conditions":["Eye Health","Vision","Cognitive Function"],"enrollment":15,"completionDate":"2023-02-03"},{"nctId":"NCT05481450","phase":"NA","title":"Efficacy and Safety Safety of Nutritears® in Adults With Dry Eye Syndrome","status":"COMPLETED","sponsor":"Applied Science & Performance Institute","startDate":"2022-08-15","conditions":["Dry Eye","Dry Eye Syndromes"],"enrollment":131,"completionDate":"2023-05-22"},{"nctId":"NCT04779411","phase":"","title":"Online Validation of Dietary Intake Food Frequency Questionnaire Over Four Weeks, and Electronic Device Use Questionnaire Over Eight Weeks.","status":"COMPLETED","sponsor":"The University of Queensland","startDate":"2020-08-18","conditions":["Lutein and Zeaxanthin Dietary Intake","Age Related Macular Degeneration","Blue Light Exposure","Electronic Device Use"],"enrollment":183,"completionDate":"2022-10-01"},{"nctId":"NCT05177679","phase":"NA","title":"Enhancing Children's Cognitive Function and Achievement Through Carotenoid Consumption","status":"RECRUITING","sponsor":"University of Illinois at Urbana-Champaign","startDate":"2022-06-23","conditions":["Cognitive Change","Achievement","Macular Pigmentation"],"enrollment":288,"completionDate":"2026-04-30"},{"nctId":"NCT05646693","phase":"PHASE2","title":"Effect of Combined Antioxidant Therapy on Oxidative Stress Markers and Inflammatory Cytokines in Patients With Tinnitus","status":"UNKNOWN","sponsor":"University of Guadalajara","startDate":"2022-12-01","conditions":["Tinnitus, Subjective","Tinnitus, Bilateral","Antioxidant Therapy","Psychiatric Drugs","Oxidative Stress","Inflammatory Cytokines","SSRI"],"enrollment":58,"completionDate":"2024-12-31"},{"nctId":"NCT05794074","phase":"NA","title":"Role of Xanthophylls in Visual Function","status":"NOT_YET_RECRUITING","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2023-04-01","conditions":["Nutrition Deficiency (Xanth Deficiency) Due to A Particular Kind of Food"],"enrollment":48,"completionDate":"2027-03-01"},{"nctId":"NCT05283941","phase":"NA","title":"Pistachios and Neural Macular Pigment","status":"UNKNOWN","sponsor":"Tufts University","startDate":"2022-06-10","conditions":["Macular Degeneration","Retinal Degeneration","Retinal Diseases","Eye Diseases"],"enrollment":40,"completionDate":"2023-11-30"},{"nctId":"NCT04761341","phase":"PHASE4","title":"FLIO and the Influence of Oral Lutein Supplementation on Macular Pigment","status":"COMPLETED","sponsor":"Insel Gruppe AG, University Hospital Bern","startDate":"2018-06-01","conditions":["Age Related Macular Degeneration"],"enrollment":28,"completionDate":"2019-10-22"},{"nctId":"NCT03959592","phase":"PHASE1,PHASE2","title":"Macular Pigment and Visual Performance in Glaucoma Patients","status":"TERMINATED","sponsor":"Felipe Medeiros, MD","startDate":"2019-08-21","conditions":["Glaucoma"],"enrollment":8,"completionDate":"2021-11-09"},{"nctId":"NCT04234334","phase":"NA","title":"Benefits of Eggs in Combination With a Plant-based Diet","status":"COMPLETED","sponsor":"University of Connecticut","startDate":"2020-01-13","conditions":["Coronary Artery Disease","Diabetes","Metabolic Syndrome"],"enrollment":24,"completionDate":"2022-08-31"},{"nctId":"NCT03932305","phase":"NA","title":"Randomized Controlled Trial of LUtein as a Novel Neuroprotective Adjunctive Therapy to Improve Visual Outcome of Rhegmatogenous Retinal Detachment (LUNAR Study)","status":"COMPLETED","sponsor":"Singapore National Eye Centre","startDate":"2016-07-25","conditions":["Retinal Detachment"],"enrollment":110,"completionDate":"2020-11-30"},{"nctId":"NCT04676126","phase":"PHASE4","title":"Augmented Macular Pigment-containing Nutraceutical and Central Visual Function","status":"WITHDRAWN","sponsor":"University of the Incarnate Word","startDate":"2021-05","conditions":["Glaucoma","Glaucoma Eye","Glaucoma, Open-Angle"],"enrollment":0,"completionDate":"2022-05"},{"nctId":"NCT01803594","phase":"NA","title":"Feeding Trial to Determine How Combinations of Different Dietary Bioactive Ingredients Influence High Density Lipoprotein (HDL) Metabolism","status":"COMPLETED","sponsor":"University of California, Davis","startDate":"2012-08","conditions":["Dyslipidemia"],"enrollment":18,"completionDate":"2015-03-13"},{"nctId":"NCT05527106","phase":"NA","title":"Evaluation of the Effect of Citicoline and Docosahexaenoic Acid (DHA) on the Visual Function of Patients With Glaucoma","status":"COMPLETED","sponsor":"Institut Catala de Retina","startDate":"2015-03-12","conditions":["Glaucoma"],"enrollment":73,"completionDate":"2022-05-25"},{"nctId":"NCT04779398","phase":"","title":"Association of MPOD Values With Blue Light.","status":"COMPLETED","sponsor":"The University of Queensland","startDate":"2020-09-25","conditions":["Age Related Macular Degeneration"],"enrollment":96,"completionDate":"2022-03-31"},{"nctId":"NCT04071977","phase":"PHASE2","title":"Combined Antioxidant Therapy on Oxidative Stress in Aqueous and Vitreous Humor of Diabetic Retinopathy Patients","status":"COMPLETED","sponsor":"University of Guadalajara","startDate":"2020-03-25","conditions":["Diabetic Retinopathy","Oxidative Stress","Diabetes"],"enrollment":40,"completionDate":"2021-12-31"},{"nctId":"NCT03702374","phase":"PHASE3","title":"Combined Antioxidant Therapy on Oxidative Stress, Mitochondrial Dysfunction Markers in Diabetic Retinopathy","status":"COMPLETED","sponsor":"University of Guadalajara","startDate":"2018-09-26","conditions":["Diabetic Retinopathy"],"enrollment":132,"completionDate":"2020-12-31"},{"nctId":"NCT05130905","phase":"NA","title":"RiteStart Personal Nutritional Dietary Study","status":"COMPLETED","sponsor":"4Life Research, LLC","startDate":"2017-09-01","conditions":["Healthy Nutrition"],"enrollment":20,"completionDate":"2017-12-20"},{"nctId":"NCT04460365","phase":"NA","title":"European Nutrition in Glaucoma Management Trial","status":"COMPLETED","sponsor":"Centre for Eye Research Ireland","startDate":"2017-10-01","conditions":["Glaucoma, Open-Angle"],"enrollment":64,"completionDate":"2020-09-17"},{"nctId":"NCT04786392","phase":"PHASE1","title":"Food or Supplemental Lutein Absorption","status":"WITHDRAWN","sponsor":"The University of Queensland","startDate":"2021-06","conditions":["Macula Lutea Opacity"],"enrollment":0,"completionDate":"2021-06"},{"nctId":"NCT04117022","phase":"NA","title":"Diabetic Retinopathy Functional Evaluation Study: Monitoring Carotenoid Vitamins Treatment Using ERG","status":"UNKNOWN","sponsor":"ZeaVision, LLC","startDate":"2019-09-01","conditions":["Diabetes","Diabetic Retinopathy"],"enrollment":45,"completionDate":"2022-12-01"},{"nctId":"NCT04843813","phase":"NA","title":"Effects of Lutein Supplementation on Cognition and MPOD in Multiple Sclerosis Patients-","status":"UNKNOWN","sponsor":"University of Illinois at Urbana-Champaign","startDate":"2021-03-26","conditions":["Multiple Sclerosis"],"enrollment":60,"completionDate":"2023-03"},{"nctId":"NCT03433885","phase":"","title":"Wenzhou Dry Age-related Macular Degeneration (AMD) Progression Study","status":"UNKNOWN","sponsor":"The Eye Hospital of Wenzhou Medical University","startDate":"2018-01-01","conditions":["Macular Pigment Optical Density"],"enrollment":300,"completionDate":"2023-12-31"},{"nctId":"NCT04741763","phase":"NA","title":"\"Night Vision and Carotenoids\"","status":"COMPLETED","sponsor":"Robert Davis","startDate":"2018-02-13","conditions":["Macular Degeneration"],"enrollment":27,"completionDate":"2020-08-20"},{"nctId":"NCT03769779","phase":"NA","title":"Evaluation of the Benefits of FloraGLO™ Lutein on Skin Health","status":"COMPLETED","sponsor":"Kemin Foods LC","startDate":"2019-03-06","conditions":["Aging","Wrinkle","Skin Elasticity","Healthy","Hydration"],"enrollment":60,"completionDate":"2020-03-30"},{"nctId":"NCT03340103","phase":"NA","title":"Early Administration of the Lutein/Zeaxanthin in Premature Newborns","status":"WITHDRAWN","sponsor":"Sooft Italia","startDate":"2018-10-11","conditions":["Antioxidant Role of the Lutein in Preterm Newborn"],"enrollment":0,"completionDate":"2019-10-11"},{"nctId":"NCT04564690","phase":"NA","title":"Enriched QUARTET® Hen Eggs and Cardiovascular Function","status":"UNKNOWN","sponsor":"Josip Juraj Strossmayer University of Osijek","startDate":"2020-10-01","conditions":["n-3 Polyunsaturated Fatty Acids","Selenium","Vitamin E","Lutein"],"enrollment":100,"completionDate":"2022-07-01"},{"nctId":"NCT03983525","phase":"NA","title":"The Effect of Gojiberry Intake (Lycium Barbarium) on Macular Function","status":"COMPLETED","sponsor":"University of California, Davis","startDate":"2019-06-10","conditions":["Macular Pigment Optical Density"],"enrollment":31,"completionDate":"2020-06-15"},{"nctId":"NCT03862872","phase":"NA","title":"Effects of Bend Beauty's Anti-Aging Formula on Inflammatory Markers","status":"WITHDRAWN","sponsor":"Bend Beauty Inc.","startDate":"2020-02","conditions":["Inflammation","Skin Abnormalities","Skin Pigment","Inflammatory Response","Skin Inflammation"],"enrollment":0,"completionDate":"2021-06"},{"nctId":"NCT00909090","phase":"NA","title":"Macular Pigment and Glare Disability","status":"COMPLETED","sponsor":"University of Georgia","startDate":"2009-05","conditions":["Vision, Entoptic"],"enrollment":109,"completionDate":"2012-12"},{"nctId":"NCT03771807","phase":"NA","title":"Efficacy of a Nutritional Supplement on Skin Health in Generally Healthy Adults","status":"COMPLETED","sponsor":"Pharmanex","startDate":"2020-01-14","conditions":["Skin Health"],"enrollment":60,"completionDate":"2020-06-20"},{"nctId":"NCT04462939","phase":"NA","title":"Study to Learn About the Effect of Elevit (a Food Supplement Containing Several Vitamins, Minerals, Lutein and DHA) on the Nutrient Content in the Breast Milk and Blood of Women During Breastfeeding Period and on Babies' Physical Growth Parameters","status":"COMPLETED","sponsor":"Bayer","startDate":"2017-04-26","conditions":["Healthy Lactating Mother"],"enrollment":68,"completionDate":"2019-11-12"},{"nctId":"NCT03866005","phase":"NA","title":"Prospective Study of Adjunctive Carotenoids Plus Anti-oxidants in Anti-VEGF Treated Diabetic Macular Edema","status":"UNKNOWN","sponsor":"ZeaVision, LLC","startDate":"2019-11-01","conditions":["Center-involved Diabetic Macular Edema (CI-DME)"],"enrollment":150,"completionDate":"2021-11-01"},{"nctId":"NCT04177069","phase":"","title":"Evaluate the Improving Effects of Visucomplex Plus on Quality of Life in Patients With AMD","status":"UNKNOWN","sponsor":"VISUfarma SpA","startDate":"2019-12-11","conditions":["AMD"],"enrollment":160,"completionDate":"2020-12-30"},{"nctId":"NCT03811977","phase":"NA","title":"The Effect of 12-Week Dietary Intake of Lutein on Minimal Erythema Dose and Other Skin Parameters","status":"COMPLETED","sponsor":"VIST - Faculty of Applied Sciences","startDate":"2019-03-04","conditions":["Minimal Erythema Dose","Skin Viscoelasticity","Dermis Density"],"enrollment":30,"completionDate":"2019-08-30"},{"nctId":"NCT00672230","phase":"NA","title":"Dietary Lutein and the Retinopathy of Prematurity","status":"COMPLETED","sponsor":"Oregon Health and Science University","startDate":"2005-08","conditions":["Lactation"],"enrollment":212,"completionDate":"2009-07"},{"nctId":"NCT03413267","phase":"NA","title":"Impact of Food Structure on Micronutrient Bioavailability in Human","status":"COMPLETED","sponsor":"Françoise Nau","startDate":"2017-12-07","conditions":["Food Structure Impact on Micronutrient Bioavailability"],"enrollment":12,"completionDate":"2018-04-19"},{"nctId":"NCT01778231","phase":"NA","title":"Investigation of the Genetic and Environmental Determinants of MP Including Response to Supplementation","status":"COMPLETED","sponsor":"Queen's University, Belfast","startDate":"2011-03","conditions":["Healthy"],"enrollment":56,"completionDate":"2013-12"},{"nctId":"NCT00596024","phase":"PHASE2","title":"Lutein and Alzheimer's Disease Study","status":"TERMINATED","sponsor":"Oregon Health and Science University","startDate":"2007-12","conditions":["Alzheimer's Disease"],"enrollment":3,"completionDate":"2009-07"},{"nctId":"NCT01620567","phase":"NA","title":"Consumption of Potatoes, Avocados and Chickpeas and Cognitive Function in Older Adults","status":"COMPLETED","sponsor":"Tufts University","startDate":"2012-08","conditions":["Mild Cognitive Impairment"],"enrollment":48,"completionDate":"2014-08"},{"nctId":"NCT03068377","phase":"NA","title":"The Effects of LycoRed Phytonutrient and Vitamin Supplement (a.k.a. LYC-001e) on Ocular Blood Flow","status":"COMPLETED","sponsor":"LycoRed Ltd.","startDate":"2017-03-20","conditions":["Ocular Blood Flow"],"enrollment":60,"completionDate":"2018-12-30"},{"nctId":"NCT02200263","phase":"NA","title":"The Effects of Lutein and Zeaxanthin Supplementation on Vision in Patients With Albinism","status":"COMPLETED","sponsor":"Johns Hopkins University","startDate":"2014-11","conditions":["Ocular Albinism (OA)","Oculocutaneous Albinism (OCA)"],"enrollment":10,"completionDate":"2018-04"},{"nctId":"NCT03113864","phase":"NA","title":"Effects of Lutein on Visual Function","status":"TERMINATED","sponsor":"Kemin Foods LC","startDate":"2017-04-15","conditions":["Healthy","Nutrition Poor"],"enrollment":14,"completionDate":"2018-06-30"},{"nctId":"NCT01566305","phase":"NA","title":"Effects of Buttermilk on Serum LDL Cholesterol Concentrations","status":"COMPLETED","sponsor":"Maastricht University Medical Center","startDate":"2010-10","conditions":["Hypercholesterolemia","Buttermilk","Dietary Modification","Cardiovascular Disease"],"enrollment":108,"completionDate":"2012-12-01"},{"nctId":"NCT02136303","phase":"NA","title":"Regional Kale as Source of Lutein and Zeaxanthin to Improve Vision of AMD-patients","status":"UNKNOWN","sponsor":"University of Jena","startDate":"2015-02","conditions":["Changes in Macular Pigment Optical Density"],"enrollment":90,"completionDate":"2020-12"},{"nctId":"NCT00527553","phase":"NA","title":"The Effect of Eggs and Egg Products on Macular Pigment","status":"COMPLETED","sponsor":"Maastricht University Medical Center","startDate":"2007-10","conditions":["Age-related Macular Degeneration"],"enrollment":100,"completionDate":"2008-02"},{"nctId":"NCT00636350","phase":"PHASE1","title":"Bioavailability of Pepper Carotenoids in Humans","status":"COMPLETED","sponsor":"Tufts University","startDate":"2007-09","conditions":["Healthy"],"enrollment":5,"completionDate":"2010-06-30"},{"nctId":"NCT01621646","phase":"NA","title":"The Effect of Daily Consumption of Eggs on Cognitive Function in the Elderly","status":"COMPLETED","sponsor":"Tufts University","startDate":"2012-07","conditions":["Mild Cognitive Impairment"],"enrollment":44,"completionDate":"2015-08"},{"nctId":"NCT01859390","phase":"PHASE2","title":"Effects of an Antioxidant-Enriched Multivitamin Supplement on Inflammation and Oxidative Stress in Cystic Fibrosis","status":"COMPLETED","sponsor":"University of Colorado, Denver","startDate":"2013-06","conditions":["Cystic Fibrosis"],"enrollment":73,"completionDate":"2016-07"},{"nctId":"NCT00121589","phase":"PHASE1","title":"Lutein/Zeaxanthin and Omega-3 Supplementation in Persons Over Age 60","status":"COMPLETED","sponsor":"National Eye Institute (NEI)","startDate":"2005-07-14","conditions":["Macular Degeneration"],"enrollment":40,"completionDate":"2007-08-15"},{"nctId":"NCT01558193","phase":"NA","title":"The Impact of Supplementation With Multi-vitamins/Minerals, With and Without Fatty Acids, on Impulsivity and Aggression","status":"COMPLETED","sponsor":"Swansea University","startDate":"2011-03","conditions":["Aggression"],"enrollment":202,"completionDate":"2011-07"},{"nctId":"NCT02457078","phase":"NA","title":"Investigating the Effects of Nutrition on the Maturation of Brain Networks Associated With Memory in Infants","status":"UNKNOWN","sponsor":"University of Illinois at Urbana-Champaign","startDate":"2015-02","conditions":["Healthy"],"enrollment":60,"completionDate":"2018-12"},{"nctId":"NCT01819415","phase":"NA","title":"Omega-3 Supplementation and Vitreal VEGF Levels in Wet-AMD","status":"COMPLETED","sponsor":"Maisonneuve-Rosemont Hospital","startDate":"2011-02","conditions":["Exudative Age Related Macular Degeneration"],"enrollment":40,"completionDate":"2013-02"},{"nctId":"NCT01653184","phase":"NA","title":"Effect of Omega-3-fatty Acids on Blood Levels Omega-3 Fatty Acids in Patients With Age-related Macular Degeneration","status":"COMPLETED","sponsor":"Wills Eye","startDate":"2012-07","conditions":["Macular Degeneration"],"enrollment":30,"completionDate":"2014-03"},{"nctId":"NCT01694680","phase":"NA","title":"Intervention Trial in Early Age-related Macular Degeneration","status":"COMPLETED","sponsor":"Newtricious R&D BV","startDate":"2012-10","conditions":["Age-related Macular Degeneration (AMD)"],"enrollment":120,"completionDate":"2016-04"},{"nctId":"NCT02450227","phase":"NA","title":"Carotenoid Absorption and Metabolism From Green-leafy Vegetable Matrices","status":"TERMINATED","sponsor":"University of Copenhagen","startDate":"2015-01","conditions":["Ileostomy; Functional Disturbance","Healthy"],"enrollment":22,"completionDate":"2015-12"},{"nctId":"NCT01621789","phase":"PHASE3","title":"Efficacy of Lutein, Zeaxanthine and Trypan Blue to Stain the Anterior Lens Capsule","status":"COMPLETED","sponsor":"Federal University of São Paulo","startDate":"2012-06","conditions":["Cataract"],"enrollment":25,"completionDate":"2014-05"},{"nctId":"NCT01627977","phase":"PHASE3","title":"Association of Lutein, Zeaxanthin and Brilliant Blue in Chromovitrectomy","status":"COMPLETED","sponsor":"Federal University of São Paulo","startDate":"2012-10","conditions":["Epiretinal Membrane","Macular Hole","Proliferative Diabetic Retinopathy"],"enrollment":18,"completionDate":"2014-03"},{"nctId":"NCT02257801","phase":"PHASE2","title":"Effects of Lutein on Learning and Memory in Chronically Stressed Subjects and in an Acute Stressful Situation (TSST - Trier Social Stress Test): A Randomized, Double-blind, Placebo-controlled Trial)","status":"COMPLETED","sponsor":"dsm-firmenich Switzerland AG","startDate":"2013-01","conditions":["Healthy But Chronically Stressed"],"enrollment":150,"completionDate":"2014-12"},{"nctId":"NCT01404845","phase":"NA","title":"Macular Pigment Density Evolution in Unilateral Wet AMD Versus Non AMD Patients With or Without Lutein and Zeaxanthine Supplementation","status":"COMPLETED","sponsor":"Affordance","startDate":"2011-09","conditions":["Exudative Age-related Macular Degeneration"],"enrollment":200,"completionDate":"2015-01"},{"nctId":"NCT00563979","phase":"NA","title":"Enhancement of Macular Pigment Density by Oral Lutein Supplementation","status":"COMPLETED","sponsor":"Insel Gruppe AG, University Hospital Bern","startDate":"2007-07","conditions":["Age-Related Maculopathies"],"enrollment":80,"completionDate":"2009-12"},{"nctId":"NCT01321268","phase":"NA","title":"Safety and Efficacy of a Dietary Supplement in Females With Cellulite","status":"TERMINATED","sponsor":"dsm-firmenich Switzerland AG","startDate":"2011-05","conditions":["Cellulite (Orange Peel Skin)"],"enrollment":8,"completionDate":"2012-07"},{"nctId":"NCT02023645","phase":"NA","title":"The Effects of a Carotenoid Intervention on Cognitive Function","status":"UNKNOWN","sponsor":"University of Georgia","startDate":"2012-01","conditions":["Mild Cognitive Impairment"],"enrollment":120,"completionDate":"2015-12"},{"nctId":"NCT02017418","phase":"NA","title":"The Effects of a Zeaxanthin Intervention on Visuomotor Function","status":"COMPLETED","sponsor":"University of Georgia","startDate":"2012-02","conditions":["Behavior and Behavior Mechanisms"],"enrollment":102,"completionDate":"2014-07"},{"nctId":"NCT00345176","phase":"PHASE3","title":"Age-Related Eye Disease Study 2 (AREDS2)","status":"COMPLETED","sponsor":"National Eye Institute (NEI)","startDate":"2006-09","conditions":["Age-related Macular Degeneration","Cataract"],"enrollment":4203,"completionDate":"2012-10"},{"nctId":"NCT01364311","phase":"NA","title":"Treatment of Dry Eye With Supplements","status":"WITHDRAWN","sponsor":"Medical University of Vienna","startDate":"2011-07","conditions":["Dry Eye Syndromes"],"enrollment":0,"completionDate":"2014-11"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{"route":"Oral","formulation":"Capsule, Gum, Powder, Tablet","formulations":[{"form":"CAPSULE","route":"ORAL","productName":"Ocuvel"},{"form":"CAPSULE","route":"ORAL","productName":"Vista Advanced Carotenoid Formula"},{"form":"GUM, CHEWING","route":"ORAL","productName":"Furryden Dental Easy Green"},{"form":"POWDER","route":"ORAL","productName":"Noon for Kids"},{"form":"TABLET","route":"ORAL","productName":"Strovite One Caplets"}]},"crossReferences":{"NUI":"N0000171226","MMSL":"117565","NDDF":"008098","UNII":"X72A60C9MT","VUID":"4024342","CHEBI":"CHEBI:28838","VANDF":"4024342","RXNORM":"11359","UMLSCUI":"C0043328","chemblId":"CHEMBL173929","ChEMBL_ID":"CHEMBL173929","DRUGBANK_ID":"DB00137","PDB_CHEM_ID":" LUT","PUBCHEM_CID":"5281243","MESH_DESCRIPTOR_UI":"D014975"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":7265,"therapeuticAreas":["Ophthalmology"],"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"","enrichmentLevel":3,"visitCount":0,"regulatoryByCountry":[{"country_code":"US","regulator":"FDA","status":"approved","approval_date":null,"mah":"","brand_name_local":null,"application_number":""},{"country_code":"CA","regulator":"Health Canada","status":"approved","approval_date":null,"mah":"","brand_name_local":"","application_number":""},{"country_code":"IL","regulator":"MOH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"SG","regulator":"HSA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"AE","regulator":"MOH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"KR","regulator":"MFDS","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"AU","regulator":"TGA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"GB","regulator":"MHRA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null}],"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T01:57:27.473413+00:00","fieldsConflicting":16,"overallConfidence":0.8},"verificationStatus":"verified","dataCompleteness":{"mechanism":false,"indications":true,"safety":true,"trials":true,"score":3}}