{"id":"luspatercept-injection-reblozyl","safety":{"commonSideEffects":[{"rate":"20%","effect":"Fatigue"},{"rate":"15%","effect":"Headache"},{"rate":"10%","effect":"Arthralgia"}]},"_chembl":{"chemblId":"CHEMBL3039545","moleculeType":"Protein"},"_dailymed":null,"mechanism":{"_ai_source":"featherless-qwen","explanation":"By binding to growth differentiation factor 11 (GDF11) and activin A, luspatercept prevents their interaction with the activin type II receptor, thereby reducing inhibitory signals in the bone marrow and promoting the maturation of red blood cells.","oneSentence":"Luspatercept is a recombinant fusion protein that acts as a ligand trap for members of the TGF-β superfamily, modulating Smad2/3 signaling to enhance erythroid maturation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T03:38:48.878Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Myelodysplastic syndromes (MDS) with ring sideroblasts"},{"name":"Beta-thalassemia"}]},"trialDetails":[],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["ACE-536"],"phase":"phase_2","status":"active","brandName":"Luspatercept Injection [Reblozyl]","genericName":"Luspatercept Injection [Reblozyl]","companyName":"Groupe Francophone des Myelodysplasies","companyId":"groupe-francophone-des-myelodysplasies","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Luspatercept is a recombinant fusion protein that acts as a ligand trap for members of the TGF-β superfamily, modulating Smad2/3 signaling to enhance erythroid maturation. Used for Myelodysplastic syndromes (MDS) with ring sideroblasts, Beta-thalassemia.","enrichmentLevel":3,"visitCount":3,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}