{"id":"lung-lavage-with-surfactant","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypoxemia during procedure"},{"rate":null,"effect":"Transient respiratory distress"},{"rate":null,"effect":"Infection risk"},{"rate":null,"effect":"Bronchoalveolar lavage-related complications"}]},"_chembl":{"chemblId":"CHEMBL1201447","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This procedure involves repeated washing of the lungs with saline containing exogenous surfactant to clear accumulated proteins, lipids, and cellular debris that impair gas exchange. Surfactant replacement restores the natural surface-active properties of the alveolar lining, reducing surface tension and improving lung compliance and oxygenation. The technique is used primarily in pulmonary alveolar proteinosis (PAP) where abnormal surfactant accumulation occurs.","oneSentence":"Lung lavage with surfactant mechanically removes proteinaceous material from the lungs while surfactant replacement improves alveolar function and gas exchange.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:53:35.956Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Pulmonary alveolar proteinosis (PAP)"}]},"trialDetails":[{"nctId":"NCT04811274","phase":"","title":"Macrophages, GM-CSF and MARS Proteinosis","status":"COMPLETED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2021-06-07","conditions":"Pulmonary Alveolar Proteinosis (PAP), MARS, Genetic Mutation","enrollment":20},{"nctId":"NCT06001645","phase":"","title":"Laboratory Biomarkers and Pulmonary Interstitial Emphysema in ARDS (PIE-ARDS)","status":"RECRUITING","sponsor":"Università Vita-Salute San Raffaele","startDate":"2023-11-27","conditions":"Acute Respiratory Distress Syndrome, Barotrauma","enrollment":110},{"nctId":"NCT03959384","phase":"PHASE3","title":"Efficacy and Safety of Curosurf® in Patients Invasively Ventilated for Severe Bronchiolitis Under 12 Months of Age","status":"TERMINATED","sponsor":"Azienda Ospedaliera Universitaria Integrata Verona","startDate":"2019-01-09","conditions":"Bronchiolitis, Viral","enrollment":9},{"nctId":"NCT02041546","phase":"PHASE4","title":"Lung Lavage With Dilute Poractant Alfa for Meconium Aspiration Syndrome","status":"COMPLETED","sponsor":"Zekai Tahir Burak Women's Health Research and Education Hospital","startDate":"2013-09","conditions":"Meconium Aspiration Syndrome","enrollment":30},{"nctId":"NCT02019095","phase":"","title":"Clinical and Biological Markers in Acute Respiratory Failure","status":"COMPLETED","sponsor":"University of Athens","startDate":"2013-12","conditions":"Ventilator-Associated Pneumonia, Acute Respiratory Distress Syndrome","enrollment":55},{"nctId":"NCT01310621","phase":"NA","title":"Comparison Of Surfactant Lung Lavage With Standard Care In The Treatment Of Meconium Aspiration Syndrome","status":"COMPLETED","sponsor":"Lady Hardinge Medical College","startDate":"2011-01","conditions":"Meconium Aspiration Syndrome","enrollment":60},{"nctId":"NCT01378624","phase":"NA","title":"Ex Vivo Effect of Surfactant Protein D on Pulmonary Cells in Patients With Asthma and Pilot Study to Assess Local Inflammation Induced by Segmental Allergen Challenge by Magnetic Resonance Imaging","status":"COMPLETED","sponsor":"Fraunhofer-Institute of Toxicology and Experimental Medicine","startDate":"2011-06","conditions":"Mild Intermittent Asthma (Gina 1)","enrollment":15},{"nctId":"NCT00004500","phase":"PHASE3","title":"Phase III Randomized Study of Lucinactant in Full Term Newborn Infants With Meconium Aspiration Syndrome","status":"TERMINATED","sponsor":"Windtree Therapeutics","startDate":"2000-03","conditions":"Meconium Aspiration","enrollment":69},{"nctId":"NCT00771992","phase":"NA","title":"Ex Vivo Effect of Surfactant Protein D on Pulmonary Immune Cells Derived From Bronchoalveolar Lavage After Segmental Allergen Challenge in Patients With Asthma","status":"COMPLETED","sponsor":"Fraunhofer-Institute of Toxicology and Experimental Medicine","startDate":"2008-10","conditions":"Asthma","enrollment":15},{"nctId":"NCT00312507","phase":"PHASE3","title":"Surfactant Lavage vs. Bolus Surfactant in Neonates With Meconium Aspiration","status":"UNKNOWN","sponsor":"The Hospital for Sick Children","startDate":"2006-04","conditions":"Meconium Aspiration Syndrome","enrollment":20}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Poractant alfa"],"phase":"marketed","status":"active","brandName":"Lung lavage with surfactant","genericName":"Lung lavage with surfactant","companyName":"Zekai Tahir Burak Women's Health Research and Education Hospital","companyId":"zekai-tahir-burak-women-s-health-research-and-education-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Lung lavage with surfactant mechanically removes proteinaceous material from the lungs while surfactant replacement improves alveolar function and gas exchange. Used for Pulmonary alveolar proteinosis (PAP).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}