{"id":"luliconazole-cream-1","safety":{"commonSideEffects":[{"rate":null,"effect":"Application site irritation"},{"rate":null,"effect":"Application site erythema"},{"rate":null,"effect":"Contact dermatitis"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"As an imidazole antifungal, luliconazole blocks the cytochrome P450-dependent enzyme lanosterol 14α-demethylase, which is essential for converting lanosterol to ergosterol in fungi. This disruption of ergosterol biosynthesis compromises the integrity and permeability of the fungal cell membrane, leading to cell death. The topical cream formulation delivers high local concentrations to affected skin.","oneSentence":"Luliconazole inhibits fungal lanosterol 14α-demethylase, disrupting ergosterol synthesis in the fungal cell membrane.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:53:37.821Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Tinea pedis (athlete's foot)"},{"name":"Tinea cruris (jock itch)"},{"name":"Tinea corporis (ringworm)"}]},"trialDetails":[{"nctId":"NCT07333170","phase":"PHASE4","title":"Comparison of the Efficacy of Topical Luliconazole 2% Cream vs Topical Ketoconazole 1% Cream in the Treatment of Pityriasis Versicolor.","status":"NOT_YET_RECRUITING","sponsor":"PAEC General Hospital, Islamabad","startDate":"2026-02","conditions":"Pityriasis Versicolor","enrollment":86},{"nctId":"NCT02394340","phase":"PHASE4","title":"Study Evaluating the Drug Interaction Potential of Luliconazole Cream 1% in Participants With Tinea Pedis and Tinea Cruris","status":"COMPLETED","sponsor":"Bausch & Lomb Incorporated","startDate":"2015-02-03","conditions":"Tinea Pedis, Tinea Cruris","enrollment":20},{"nctId":"NCT02767271","phase":"PHASE4","title":"Maximal Use of Luliconazole Cream 1% in Pediatric Participants With Moderate to Severe Tinea Pedis or Tinea Cruris","status":"COMPLETED","sponsor":"Bausch Health Americas, Inc.","startDate":"2015-12-02","conditions":"Tinea Pedis, Tinea Cruris","enrollment":30},{"nctId":"NCT02767947","phase":"PHASE4","title":"Safety and Efficacy of Product 33525 (Luliconazole Cream 1%) in Pediatric Participants With Tinea Corporis","status":"COMPLETED","sponsor":"Bausch Health Americas, Inc.","startDate":"2016-02-08","conditions":"Tinea Corporis","enrollment":75},{"nctId":"NCT00869336","phase":"PHASE2","title":"Multicenter Study of the Efficacy and Safety of Luliconazole Cream in Tinea Pedis (Athlete's Foot)","status":"COMPLETED","sponsor":"Tinea Pharmaceuticals","startDate":"2009-03","conditions":"Tinea Pedis","enrollment":147}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":6,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Product 33525","LUZU Cream 1%"],"phase":"marketed","status":"active","brandName":"Luliconazole Cream 1%","genericName":"Luliconazole Cream 1%","companyName":"Bausch Health Americas, Inc.","companyId":"bausch-health-americas-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Luliconazole inhibits fungal lanosterol 14α-demethylase, disrupting ergosterol synthesis in fungal cell membranes. Used for Tinea corporis (ringworm of the body), Tinea cruris (jock itch), Tinea pedis (athlete's foot).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":3,"withResults":3},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}