{"id":"lubricant-eye-drops-optive","safety":{"commonSideEffects":[{"rate":null,"effect":"Ocular irritation"},{"rate":null,"effect":"Blurred vision"},{"rate":null,"effect":"Eye discomfort"}]},"_chembl":{"chemblId":"CHEMBL2107924","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Optive is a preservative-free lubricating eye drop formulation containing carboxymethylcellulose sodium and glycerin, which work together to hydrate and coat the cornea and conjunctiva. The formulation provides sustained lubrication and protection for dry eye symptoms by reducing friction and maintaining tear film stability on the ocular surface.","oneSentence":"Optive lubricates and protects the ocular surface by providing a multi-component tear substitute that mimics natural tears.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:53:34.166Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Dry eye disease / Keratoconjunctivitis sicca"},{"name":"Ocular surface lubrication and protection"}]},"trialDetails":[{"nctId":"NCT00610480","phase":"NA","title":"Tear Film Stability After Instillation of Over-the-Counter (OTC) Artificial Drops","status":"COMPLETED","sponsor":"University of Texas Southwestern Medical Center","startDate":"2007-11","conditions":"Dry Eye Disease","enrollment":20},{"nctId":"NCT01664949","phase":"PHASE3","title":"A Study to Compare the Safety and Efficacy of A New Eye Drop Formulation With OPTIVE™ in Subjects With Dry Eye Disease","status":"COMPLETED","sponsor":"Allergan","startDate":"2013-01","conditions":"Dry Eye Disease","enrollment":460},{"nctId":"NCT01417013","phase":"NA","title":"Comparative Efficacy of SYSTANE® ULTRA vs Optive™ in Improving Tear Film Break-up Time","status":"WITHDRAWN","sponsor":"Alcon Research","startDate":"2011-07","conditions":"Dry Eye","enrollment":""},{"nctId":"NCT01368198","phase":"NA","title":"Evaluation of Extended Tear Film Break Up Time (TFBUT) With an Ocular Emulsion","status":"COMPLETED","sponsor":"Alcon Research","startDate":"2011-03","conditions":"Dry Eye","enrollment":50},{"nctId":"NCT00756678","phase":"PHASE4","title":"Efficacy and Acceptability of Two Lubricant Eye Drops","status":"COMPLETED","sponsor":"Allergan","startDate":"2008-09","conditions":"Dry Eye Syndromes","enrollment":51},{"nctId":"NCT00938704","phase":"PHASE4","title":"Study to Compare the Efficacy and Safety of Two Non-Preserved Artificial Tears for the Treatment of Dry Eye Signs and Symptoms","status":"COMPLETED","sponsor":"Allergan","startDate":"2009-06","conditions":"Dry Eye Syndromes","enrollment":71}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":14,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Optive™"],"phase":"marketed","status":"active","brandName":"Lubricant Eye Drops (Optive™)","genericName":"Lubricant Eye Drops (Optive™)","companyName":"Allergan","companyId":"allergan","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Optive lubricates and protects the ocular surface by providing a multi-component tear substitute that mimics natural tears. Used for Dry eye disease / Keratoconjunctivitis sicca, Ocular surface lubrication and protection.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}