{"id":"ltot-24-h-day","safety":{"commonSideEffects":[{"rate":null,"effect":"Nasal dryness and irritation"},{"rate":null,"effect":"Skin breakdown from oxygen delivery device"},{"rate":null,"effect":"Oxygen toxicity (with prolonged high concentrations)"},{"rate":null,"effect":"Fire hazard risk"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Long-term oxygen therapy (LTOT) is a supportive treatment that increases inspired oxygen concentration to correct chronic hypoxemia (low blood oxygen). By delivering oxygen 24 hours daily, it reduces the work of breathing, decreases pulmonary vasoconstriction, and helps prevent secondary complications such as pulmonary hypertension and cor pulmonale in patients with chronic respiratory diseases.","oneSentence":"LTOT 24 h/day delivers supplemental oxygen continuously throughout the day and night to maintain adequate blood oxygen levels in patients with chronic hypoxemia.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:41:24.523Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chronic obstructive pulmonary disease (COPD) with chronic hypoxemia"},{"name":"Interstitial lung disease with chronic hypoxemia"},{"name":"Other chronic respiratory conditions requiring continuous oxygen supplementation"}]},"trialDetails":[{"nctId":"NCT03441204","phase":"PHASE4","title":"REgistry-based Treatment Duration and Mortality in Long-term OXygen Therapy (REDOX)","status":"COMPLETED","sponsor":"Skane University Hospital","startDate":"2018-05-16","conditions":"Chronic Respiratory Failure With Hypoxia","enrollment":241}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Long-term oxygen therapy prescribed continuously (24 h/day)"],"phase":"marketed","status":"active","brandName":"LTOT 24 h/day","genericName":"LTOT 24 h/day","companyName":"Skane University Hospital","companyId":"skane-university-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"LTOT 24 h/day delivers supplemental oxygen continuously throughout the day and night to maintain adequate blood oxygen levels in patients with chronic hypoxemia. Used for Chronic obstructive pulmonary disease (COPD) with chronic hypoxemia, Interstitial lung disease with chronic hypoxemia, Other chronic respiratory conditions requiring continuous oxygen supplementation.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}