{"id":"ltot-15h-day","safety":{"commonSideEffects":[{"rate":null,"effect":"Nasal irritation or drying"},{"rate":null,"effect":"Skin irritation from oxygen delivery device"},{"rate":null,"effect":"Oxygen-induced hypercapnia (in CO2-retaining patients)"},{"rate":null,"effect":"Fire hazard risk"}]},"_chembl":{"chemblId":"CHEMBL3698417","moleculeType":"Small molecule","molecularWeight":"540.57"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Long-term oxygen therapy (LTOT) is a supportive treatment that delivers supplemental oxygen to patients with chronic lung diseases or conditions causing persistent low blood oxygen levels. By increasing inspired oxygen concentration, LTOT improves arterial oxygen saturation, reduces pulmonary vasoconstriction, and decreases the workload on the heart and respiratory system. The 15-hour daily regimen is a standard dosing schedule used to manage chronic hypoxemia while allowing periods without supplemental oxygen.","oneSentence":"LTOT 15h/day refers to long-term oxygen therapy administered for 15 hours per day, which increases blood oxygen saturation in patients with chronic hypoxemia.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:53:29.210Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chronic hypoxemia secondary to chronic obstructive pulmonary disease (COPD)"},{"name":"Interstitial lung disease with chronic hypoxemia"},{"name":"Other chronic respiratory conditions with resting or exertional hypoxemia"}]},"trialDetails":[{"nctId":"NCT03441204","phase":"PHASE4","title":"REgistry-based Treatment Duration and Mortality in Long-term OXygen Therapy (REDOX)","status":"COMPLETED","sponsor":"Skane University Hospital","startDate":"2018-05-16","conditions":"Chronic Respiratory Failure With Hypoxia","enrollment":241}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Long-term oxygen therapy prescribed for 15 h/day"],"phase":"marketed","status":"active","brandName":"LTOT 15h/day","genericName":"LTOT 15h/day","companyName":"Skane University Hospital","companyId":"skane-university-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"LTOT 15h/day refers to long-term oxygen therapy administered for 15 hours per day, which increases blood oxygen saturation in patients with chronic hypoxemia. Used for Chronic hypoxemia secondary to chronic obstructive pulmonary disease (COPD), Interstitial lung disease with chronic hypoxemia, Other chronic respiratory conditions with resting or exertional hypoxemia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}