{"id":"loxoprofen-sodium-hydrogel-patch","safety":{"commonSideEffects":[{"rate":null,"effect":"Skin irritation at application site"},{"rate":null,"effect":"Gastrointestinal upset (if systemic absorption occurs)"},{"rate":null,"effect":"Allergic contact dermatitis"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Loxoprofen sodium blocks COX-1 and COX-2 enzymes, which are responsible for producing prostaglandins that mediate inflammation, pain, and fever. The hydrogel patch formulation provides transdermal delivery of the drug, allowing localized anti-inflammatory and analgesic effects at the site of application while potentially reducing systemic exposure compared to oral administration.","oneSentence":"Loxoprofen sodium is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation and pain.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:53:36.776Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Localized pain and inflammation (musculoskeletal pain, arthritis)"},{"name":"Transdermal pain relief"}]},"trialDetails":[{"nctId":"NCT03800797","phase":"PHASE4","title":"Efficacy and Safety of Loxoprofen Hydrogel Patch in Patients With Ankylosing Spondylitis","status":"COMPLETED","sponsor":"Sun Yat-sen University","startDate":"2015-05-25","conditions":"Ankylosing Spondylitis","enrollment":70}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Loxoprofen hydrogel patch"],"phase":"marketed","status":"active","brandName":"Loxoprofen sodium hydrogel patch","genericName":"Loxoprofen sodium hydrogel patch","companyName":"Sun Yat-sen University","companyId":"sun-yat-sen-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Loxoprofen sodium is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation and pain. Used for Localized pain and inflammation (musculoskeletal pain, arthritis), Transdermal pain relief.","enrichmentLevel":3,"visitCount":2,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}