{"id":"loxiglumide","rwe":[],"tags":[{"label":"loxiglumide","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Cholecystokinin receptor type A","category":"target"},{"label":"CCKAR","category":"gene"},{"label":"Active","category":"status"},{"label":"Hormone Antagonists","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["loxiglumide"],"offLabel":[],"synonyms":["loxiglumide"],"timeline":[],"aiSummary":"Loxiglumide is a small molecule drug that targets the cholecystokinin receptor type A. It is classified as a loxiglumide, but its commercial status and approved indications are unknown. The drug has a half-life of 5.2 hours, but its bioavailability and off-patent status are not specified. As a result, its availability and use are limited. Further research is needed to determine its potential as a therapeutic agent.","approvals":[],"ecosystem":[],"mechanism":{"target":"Cholecystokinin receptor type A, Cholecystokinin receptor type A","targets":[{"gene":"CCKAR","source":"DrugCentral","target":"Cholecystokinin receptor type A","protein":"Cholecystokinin receptor type A"}],"modality":"Small Molecule","drugClass":"loxiglumide","explanation":"Imagine your stomach is a bucket that fills up with food. Loxiglumide helps to slow down the flow of food from the stomach into the small intestine, giving your body more time to digest it properly. This can help to reduce symptoms of conditions like gastroparesis, where the stomach takes too long to empty its contents.","oneSentence":"Loxiglumide works by binding to the cholecystokinin receptor type A, which helps to slow down gastric emptying and reduce symptoms of certain gastrointestinal disorders.","technicalDetail":"Loxiglumide acts as a selective antagonist of the cholecystokinin receptor type A (CCK-A), a subtype of the cholecystokinin receptor. This receptor plays a key role in regulating gastric emptying and pancreatic enzyme secretion. By binding to the CCK-A receptor, loxiglumide inhibits the release of cholecystokinin, a hormone that stimulates gastric emptying and pancreatic enzyme secretion."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1614","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=LOXIGLUMIDE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T14:10:33.915290","biosimilars":[],"competitors":[{"drugName":"ceruletide","drugSlug":"ceruletide","fdaApproval":"","patentStatus":"Unknown","relationship":"same-target"},{"drugName":"paclitaxel","drugSlug":"paclitaxel","fdaApproval":"1992-12-29","patentExpiry":"Sep 4, 2032","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"sincalide","drugSlug":"sincalide","fdaApproval":"1976-07-21","patentExpiry":"Apr 20, 2038","patentStatus":"Patent protected","relationship":"same-target"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"loxiglumide","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"ceruletide","brandName":"ceruletide","genericName":"ceruletide","approvalYear":"","relationship":"same-target"},{"drugId":"paclitaxel","brandName":"paclitaxel","genericName":"paclitaxel","approvalYear":"1992","relationship":"same-target"},{"drugId":"sincalide","brandName":"sincalide","genericName":"sincalide","approvalYear":"1976","relationship":"same-target"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"UNII":"77MPX3N42I","CHEBI":"CHEBI:31785","INN_ID":"6113","UMLSCUI":"C0065197","ChEMBL_ID":"CHEMBL206025","KEGG_DRUG":"D01113","PUBCHEM_CID":"60182","IUPHAR_LIGAND_ID":"892","MESH_SUPPLEMENTAL_RECORD_UI":"C053737"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"pharmacokinetics":{"source":"DrugCentral","halfLife":"5.2 hours","clearance":"1.0 mL/min/kg","volumeOfDistribution":"0.24 L/kg"},"publicationCount":233,"therapeuticAreas":["Gastroenterology"],"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"LOXIGLUMIDE","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}