{"id":"lower-dose-sodium-bicarbonate","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypernatremia"},{"rate":null,"effect":"Gastrointestinal disturbance"},{"rate":null,"effect":"Alkalosis"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Sodium bicarbonate is an alkalizing agent that buffers systemic acidosis, a known contributor to kidney disease progression. By reducing metabolic acidosis through oral supplementation at lower doses than traditional use, it may slow glomerular filtration rate decline and preserve renal function. This mechanism is particularly relevant in chronic kidney disease where acidosis accelerates tubular damage and fibrosis.","oneSentence":"Lower dose sodium bicarbonate raises blood and urine pH to reduce acid load and slow progression of chronic kidney disease.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:19:40.170Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chronic kidney disease with metabolic acidosis"}]},"trialDetails":[{"nctId":"NCT05411991","phase":"PHASE4","title":"Diuretic Treatment in Acute Heart Failure With Volume Overload Guided by Serial Spot Urine Sodium Assessment","status":"COMPLETED","sponsor":"Vrije Universiteit Brussel","startDate":"2022-06-12","conditions":"Acute Heart Failure, Diuretics Drug Reactions","enrollment":107},{"nctId":"NCT06983509","phase":"","title":"Registry of Pre-mixed Solutions in Critically Ill Patients on the Continuous Renal Replacement Therapy","status":"RECRUITING","sponsor":"Vantive Health LLC","startDate":"2024-09-23","conditions":"Renal Insufficiency","enrollment":220},{"nctId":"NCT05092854","phase":"NA","title":"The Effect of AMP Human Sodium Bicarbonate Lotion on Dehydrated Heat Stress","status":"COMPLETED","sponsor":"University of Connecticut","startDate":"2021-09-03","conditions":"Fluid Retention, Sodium Retention, Heat Stress","enrollment":18},{"nctId":"NCT04752956","phase":"NA","title":"Effectiveness of Sodium Hyaluronate In Relieving Nasal Symptoms Of Children With Seasonal Allergic Rhinitis","status":"UNKNOWN","sponsor":"Saglik Bilimleri Universitesi","startDate":"2019-03-03","conditions":"Seasonal Allergic Rhinitis","enrollment":101},{"nctId":"NCT02521181","phase":"PHASE3","title":"The BASE Study: Bicarbonate Administration to Stabilize Estimated Glomerular Filtration Rate (eGFR)","status":"COMPLETED","sponsor":"Jennifer Gassman, PhD","startDate":"2015-10","conditions":"Chronic Kidney Disease","enrollment":194},{"nctId":"NCT04509258","phase":"PHASE4","title":"Effectiveness of N-acetyl Cysteine, Acetyl L- Carnitine and Medicated Paraffin Oil in Aluminium Phosphide Poisoning","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2020-10","conditions":"the Study Focus to Improve the Standard of Care Used for Aluminuim Phosphide Poisoning and to Save Patients With the Minimal Organ Damage","enrollment":100},{"nctId":"NCT02816346","phase":"PHASE1","title":"Dose-Finding Study of Lyophilized Shigella Sonnei 53G Challenge Strain","status":"COMPLETED","sponsor":"PATH","startDate":"2016-09-12","conditions":"Healthy","enrollment":56},{"nctId":"NCT02427594","phase":"PHASE1","title":"Acid-Base Compensation in Chronic Kidney Disease","status":"COMPLETED","sponsor":"Duke University","startDate":"2015-04","conditions":"Chronic Kidney Disease","enrollment":14},{"nctId":"NCT01920269","phase":"PHASE2, PHASE3","title":"Intravesical Adjuvant Electromotive Mitomycin-C","status":"COMPLETED","sponsor":"University of Rome Tor Vergata","startDate":"1994-01","conditions":"Bladder Cancer TNM Staging Primary Tumor (T) Ta, Bladder Cancer TNM Staging Primary Tumor (T) T1, Bladder Cancer Transitional Cell Grade","enrollment":331}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Lower Dose Sodium Bicarbonate","genericName":"Lower Dose Sodium Bicarbonate","companyName":"Jennifer Gassman, PhD","companyId":"jennifer-gassman-phd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Lower dose sodium bicarbonate has been studied in clinical trials for conditions including seasonal allergic rhinitis, acute heart failure, and diuretics drug reactions. The mechanism of action of sodium bicarbonate is not specified in the provided information, but it is listed as an intervention in ClinicalTrials.gov for these conditions.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}