{"id":"low-sodium-oxybate","safety":{"commonSideEffects":[{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Enuresis"},{"rate":null,"effect":"Tremor"},{"rate":null,"effect":"Anxiety"}]},"_chembl":{"chemblId":"CHEMBL1200682","moleculeType":"Small molecule","molecularWeight":"126.09"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Oxybate is a prodrug of gamma-hydroxybutyrate (GHB), which acts as a neuromodulator at GHB receptors and GABA-B receptors in the brain. By lowering sodium content while maintaining therapeutic oxybate levels, this formulation reduces sodium intake burden in patients requiring chronic oxybate therapy, particularly important for those with comorbid hypertension or cardiovascular concerns. The mechanism of action remains identical to standard sodium oxybate, but with improved tolerability regarding sodium-related adverse effects.","oneSentence":"Low sodium oxybate is a reduced-sodium formulation of sodium oxybate that enhances GABAergic and GHB receptor signaling in the central nervous system to reduce excessive daytime sleepiness and cataplexy.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:53:27.797Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Narcolepsy type 1 with cataplexy"},{"name":"Excessive daytime sleepiness in narcolepsy"}]},"trialDetails":[{"nctId":"NCT06421532","phase":"PHASE2","title":"Stimulating Amyloid Clearance in Cerebral Amyloid Angiopathy","status":"ENROLLING_BY_INVITATION","sponsor":"Leiden University Medical Center","startDate":"2025-03-27","conditions":"Cerebral Amyloid Angiopathy","enrollment":60},{"nctId":"NCT06950281","phase":"PHASE2","title":"Efficacy, Safety and Tolerability of Low Sodium Oxybate for Nocturnal Cluster Headache Attacks","status":"NOT_YET_RECRUITING","sponsor":"Leiden University Medical Center","startDate":"2026-01","conditions":"Chronic Cluster Headache","enrollment":52},{"nctId":"NCT07077278","phase":"PHASE4","title":"Effect of Low Sodium Oxybate (LXB) on Autonomic Symptom Burden in Idiopathic Hypersomnia Patients With Postural Tachycardia Syndrome","status":"NOT_YET_RECRUITING","sponsor":"Stanford University","startDate":"2025-10-01","conditions":"Idiopathic Hypersomnia, POTS - Postural Orthostatic Tachycardia Syndrome","enrollment":25},{"nctId":"NCT05875974","phase":"PHASE4","title":"A Study to Investigate the Effect of XYWAV on Sleepiness, Polysomnography, and Functional Outcomes in Participants With Idiopathic Hypersomnia or Narcolepsy","status":"COMPLETED","sponsor":"Jazz Pharmaceuticals","startDate":"2023-07-27","conditions":"Idiopathic Hypersomnia, Narcolepsy","enrollment":207},{"nctId":"NCT05837091","phase":"PHASE4","title":"Low Sodium Oxybate in Patients With Idiopathic Hypersomnia","status":"RECRUITING","sponsor":"Mayo Clinic","startDate":"2024-02-14","conditions":"Idiopathic Hypersomnia","enrollment":30}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":32,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["XYWAV","JZP-258","Xywav","Calcium, Magnesium, Potassium, and Sodium Oxybates"],"phase":"marketed","status":"active","brandName":"Low Sodium Oxybate","genericName":"Low Sodium Oxybate","companyName":"Leiden University Medical Center","companyId":"leiden-university-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Low sodium oxybate is a reduced-sodium formulation of sodium oxybate that enhances GABAergic and GHB receptor signaling in the central nervous system to reduce excessive daytime sleepiness and cataplexy. Used for Narcolepsy type 1 with cataplexy, Excessive daytime sleepiness in narcolepsy.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}