{"id":"low-phytic-acid-maize","safety":{"commonSideEffects":[]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Phytic acid (inositol hexaphosphate) is a naturally occurring compound in grains that binds minerals and reduces their absorption in the human gastrointestinal tract. By genetically reducing phytic acid levels in maize, the bioavailability of micronutrients—particularly iron and zinc—is enhanced, improving nutritional status in populations reliant on maize as a primary carbohydrate source. This addresses micronutrient deficiency, particularly in low-resource settings where dietary diversity is limited.","oneSentence":"Low phytic acid maize reduces anti-nutritional phytic acid content to improve bioavailability of essential minerals like iron and zinc in staple grain consumption.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:19:40.151Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Micronutrient deficiency (iron and zinc) in populations with maize-dependent diets"},{"name":"Malnutrition in women and children in low-resource settings"}]},"trialDetails":[{"nctId":"NCT02370940","phase":"NA","title":"Regular Consumption of High Phytate Reduces Inhibitory Effect of Phytate on Iron Absorption","status":"COMPLETED","sponsor":"Iowa State University","startDate":"2013-01","conditions":"Iron Bioavailability","enrollment":32},{"nctId":"NCT00098202","phase":"PHASE3","title":"Randomized Placebo-Controlled Trial (RPCT) of Maize/Zinc in Guatemala","status":"COMPLETED","sponsor":"NICHD Global Network for Women's and Children's Health","startDate":"2003-03","conditions":"Nutrition, Pregnancy","enrollment":420}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":5,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Low phytic acid maize","genericName":"Low phytic acid maize","companyName":"NICHD Global Network for Women's and Children's Health","companyId":"nichd-global-network-for-women-s-and-children-s-health","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Low phytic acid maize reduces anti-nutritional phytic acid content to improve bioavailability of essential minerals like iron and zinc in staple grain consumption. Used for Micronutrient deficiency (iron and zinc) in populations with maize-dependent diets, Malnutrition in women and children in low-resource settings.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}