{"id":"low-dose-pilocarpine","safety":{"commonSideEffects":[{"rate":null,"effect":"Miosis (pupil constriction)"},{"rate":null,"effect":"Accommodative spasm (blurred vision)"},{"rate":null,"effect":"Ocular discomfort or irritation"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Brow ache"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Pilocarpine binds to muscarinic receptors on the ciliary muscle and trabecular meshwork, causing contraction that mechanically opens drainage pathways for aqueous humor. At low doses, this effect reduces intraocular pressure while minimizing systemic side effects associated with higher pilocarpine concentrations. The drug has been used for decades in ophthalmology, and Ocuphire's formulation aims to optimize efficacy and tolerability for glaucoma management.","oneSentence":"Low-dose pilocarpine is a muscarinic acetylcholine receptor agonist that stimulates parasympathetic activity to increase aqueous humor outflow and reduce intraocular pressure.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:19:36.167Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Open-angle glaucoma"},{"name":"Ocular hypertension"}]},"trialDetails":[{"nctId":"NCT05646719","phase":"PHASE3","title":"Safety and Efficacy of Nyxol Eye Drops as a Single Agent and With Adjunctive Low-Dose Pilocarpine Eye Drops in Subjects With Presbyopia","status":"COMPLETED","sponsor":"Ocuphire Pharma, Inc.","startDate":"2022-12-22","conditions":"Presbyopia","enrollment":333},{"nctId":"NCT05006898","phase":"PHASE1","title":"Compound to Control Presbyopia Symptoms","status":"COMPLETED","sponsor":"Optall Vision","startDate":"2020-06-01","conditions":"Presbyopia","enrollment":11},{"nctId":"NCT04195100","phase":"EARLY_PHASE1","title":"Local Pilocarpine for Relieving Dry Mouth","status":"COMPLETED","sponsor":"Maastricht University Medical Center","startDate":"2019-04-01","conditions":"Patients of Advanced Age (≥ 70 Years) With a Clinical Diagnosis of Chronic Dry Mouth","enrollment":14},{"nctId":"NCT02447315","phase":"PHASE1","title":"A Study to Investigate the Effect of Oral Doses of Pilocarpine on Salivary Secretion and Static Pupillometry in Healthy Subjects","status":"COMPLETED","sponsor":"Astellas Pharma Europe B.V.","startDate":"2015-05","conditions":"Healthy Subjects","enrollment":12}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":20,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Pilocarpine","LDP"],"phase":"phase_3","status":"active","brandName":"Low dose pilocarpine","genericName":"Low dose pilocarpine","companyName":"Ocuphire Pharma, Inc.","companyId":"ocuphire-pharma-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Low-dose pilocarpine is a muscarinic acetylcholine receptor agonist that stimulates parasympathetic activity to increase aqueous humor outflow and reduce intraocular pressure. Used for Open-angle glaucoma, Ocular hypertension.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}