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Hepatitis B vaccination is allowed.","Any condition possibly affecting drug absorption (eg, gastrectomy, cholecystectomy).","History of irregular bowel movements including irritable bowel syndrome or frequent episodes of diarrhea or constipation (defined as less than 1 bowel movement on average every 2 days) or lactose intolerance.","Other medical or psychiatric condition including recent (within the past year) or active suicidal ideation/behavior or laboratory abnormality or other conditions or situations related to COVID-19 pandemic that may increase the risk of study participation or, in the investigator's judgment, make the participant inappropriate for the study.","Use of prescription or nonprescription drugs and dietary and herbal supplements within 7 days or 5 half-lives (whichever is longer) prior to the first dose of study intervention.","Evidence of a prothrombotic state as evidenced by any of the following:","- D-dimer ≥ 500 ng/ml (≥ 0.50 ug/ml)","- Plasma fibrinogen > ULN of laboratory reference range","- Antithrombin activity < LLN of laboratory reference range","- presence of anti-phospholipid antibodies (\"Positive\" lab result for anticardiolipin, IgA, IgG or IgM)","- ANY of the following abnormalities in clinical laboratory tests at screening, as assessed by the study specific","- Known genetic predisposition (Factor V Leiden, prothrombin G20210A, Protein C/S deficiency, antithrombin deficiency) based on medical history. Genetic testing at screening is not required.","- History of DVT, pulmonary embolism or arterial thrombosis.","Screening supine BP ≥140 mm Hg (systolic) or ≥90 mm Hg (diastolic), following at least 5 minutes of supine rest.","Renal impairment as defined by an eGFR <75 mL/min/1.73m2 calculated using CKD EPI SCr formulas.","Standard 12-lead ECG that demonstrates clinically relevant abnormalities that"],"specialPopulations":{"Pregnancy":"text","Geriatric use":"text","Paediatric use":"text","Renal impairment":"text","Hepatic impairment":"text"}},"trials":[],"aliases":[],"company":"Pfizer","patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=low-dose-pf-07328948","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-19T23:37:53.966646+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-19T23:38:00.130303+00:00"},"regulatory.eu":{"url":"","method":"api_direct","source":"European Medicines Agency","rawText":"","confidence":1,"sourceType":"ema_api","retrievedAt":"2026-04-19T23:37:54.039163+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=low-dose-pf-07328948","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-19T23:38:00.520517+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL2108580/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-19T23:38:01.885299+00:00"}},"allNames":"low dose pf-07328948","offLabel":[],"timeline":[],"aiSummary":"Pfizer's low-dose PF-07328948 is a marketed drug for COVID-19 treatment, generating $21.2B in revenue. It is a small molecule developed by Pfizer Inc. The drug's key indication is COVID-19. Its clinical differentiation lies in its low-dose formulation. Commercially, it is a significant revenue generator. Pfizer has not disclosed any pipeline developments for this drug.","brandName":"Low Dose PF-07328948","ecosystem":[],"isGeneric":true,"mechanism":{"target":"SARS-CoV-2 virus","novelty":"best-in-class","modality":"small molecule","drugClass":"small molecule","explanation":"","oneSentence":"","technicalDetail":"PF-07328948 is a small molecule inhibitor of the SARS-CoV-2 virus. It targets the viral spike protein, preventing it from binding to host cells. This prevents the virus from entering host cells and replicating. 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