{"id":"low-dose-peroral-misoprostol","safety":{"commonSideEffects":[{"rate":"10–30","effect":"Diarrhea"},{"rate":"10–20","effect":"Abdominal pain/cramping"},{"rate":"3–7","effect":"Nausea"},{"rate":"2–5","effect":"Flatulence"}]},"_chembl":{"chemblId":"CHEMBL4064157","moleculeType":"Small molecule","molecularWeight":"382.54"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Misoprostol binds to prostaglandin receptors on gastric epithelial cells, enhancing mucus and bicarbonate secretion while simultaneously decreasing gastric acid secretion. At low oral doses, it is used primarily for gastroprotection, particularly in patients taking nonsteroidal anti-inflammatory drugs (NSAIDs) who are at risk for peptic ulcer disease. The drug also has uterotonic properties at higher doses, but low-dose formulations are marketed for GI protection.","oneSentence":"Misoprostol is a prostaglandin E1 analogue that stimulates gastric mucus secretion and reduces gastric acid production to protect the gastrointestinal mucosa.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:34:10.569Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of NSAID-induced gastric ulcers"},{"name":"Gastroprotection in patients requiring chronic NSAID therapy"}]},"trialDetails":[{"nctId":"NCT06794385","phase":"PHASE4","title":"Comparison of the Effectiveness, Safety, and Satisfaction of Different Methods for Labor Induction","status":"NOT_YET_RECRUITING","sponsor":"University Medical Centre Ljubljana","startDate":"2025-01-22","conditions":"Induction of Labour","enrollment":200}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"low dose peroral misoprostol","genericName":"low dose peroral misoprostol","companyName":"University Medical Centre Ljubljana","companyId":"university-medical-centre-ljubljana","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Misoprostol is a prostaglandin E1 analogue that stimulates gastric mucus secretion and reduces gastric acid production to protect the gastrointestinal mucosa. Used for Prevention of NSAID-induced gastric ulcers, Gastroprotection in patients requiring chronic NSAID therapy.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}