{"id":"low-dose-hcg-plus-fsh-co-trigger","safety":{"commonSideEffects":[{"rate":null,"effect":"Ovarian hyperstimulation syndrome (OHSS)"},{"rate":null,"effect":"Abdominal pain or discomfort"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Headache"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This co-trigger strategy uses human chorionic gonadotropin (hCG) and follicle-stimulating hormone (FSH) together at reduced doses to stimulate the final stages of egg maturation and trigger ovulation. The combination aims to optimize oocyte quality and reduce ovarian hyperstimulation syndrome risk compared to standard hCG-alone triggers, while maintaining efficacy in controlled ovarian hyperstimulation protocols.","oneSentence":"Low-dose hCG combined with FSH acts as a dual trigger to induce final oocyte maturation and ovulation in assisted reproductive technology cycles.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:49:37.540Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Final oocyte maturation trigger in assisted reproductive technology (ART) and in vitro fertilization (IVF) cycles"}]},"trialDetails":[{"nctId":"NCT02310919","phase":"PHASE3","title":"Administration of Follicle-stimulating Hormone (FSH) and Low Dose Human Chorionic Gonadotropin (hCG) for Oocyte Maturity While Decreasing hCG Exposure in In Vitro Fertilization (IVF) Cycles","status":"COMPLETED","sponsor":"University of California, San Francisco","startDate":"2014-09","conditions":"Infertility","enrollment":105}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Low dose hCG plus FSH co-trigger","genericName":"Low dose hCG plus FSH co-trigger","companyName":"University of California, San Francisco","companyId":"university-of-california-san-francisco","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Low-dose hCG combined with FSH acts as a dual trigger to induce final oocyte maturation and ovulation in assisted reproductive technology cycles. Used for Final oocyte maturation trigger in assisted reproductive technology (ART) and in vitro fertilization (IVF) cycles.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}