{"id":"low-dose-furosemide","safety":{"commonSideEffects":[{"rate":"10-20","effect":"Hypokalemia"},{"rate":"5-10","effect":"Hyperuricemia"},{"rate":"<1","effect":"Ototoxicity (at high doses)"},{"rate":"5-15","effect":"Dehydration"},{"rate":"5-10","effect":"Hypotension"},{"rate":"5-10","effect":"Hyperglycemia"},{"rate":"1-5","effect":"Hyponatremia"}]},"_chembl":{"chemblId":"CHEMBL35","moleculeType":"Small molecule","molecularWeight":"330.75"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Furosemide is a loop diuretic that blocks the Na-K-2Cl symporter on the apical membrane of thick ascending limb cells, preventing reabsorption of approximately 20-30% of filtered sodium and chloride. This increases urine output and reduces fluid volume, lowering blood pressure and reducing edema. At low doses, the diuretic effect is modest while maintaining better electrolyte balance than standard doses.","oneSentence":"Low-dose furosemide inhibits the Na-K-2Cl cotransporter in the thick ascending limb of the loop of Henle, reducing sodium reabsorption and promoting diuresis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:41:17.935Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Edema associated with congestive heart failure"},{"name":"Edema associated with hepatic cirrhosis"},{"name":"Edema associated with renal disease"},{"name":"Hypertension"}]},"trialDetails":[{"nctId":"NCT05440851","phase":"NA","title":"Platform of Randomized Adaptive Clinical Trials in Critical Illness","status":"RECRUITING","sponsor":"University Health Network, Toronto","startDate":"2023-04-30","conditions":"Respiratory Insufficiency, Extracorporeal Membrane Oxygenation Complication, Mechanical Ventilation Pressure High","enrollment":6250},{"nctId":"NCT05668676","phase":"PHASE2, PHASE3","title":"Effect of Short-Term Prednisone Therapy on C-Reactive Protein Change in Emergency Department Patients With Acute Heart Failure and Elevated Inflammatory Markers ( CORTAHF )","status":"COMPLETED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2023-02-16","conditions":"Acute Heart Failure","enrollment":3},{"nctId":"NCT06218199","phase":"PHASE4","title":"Diuretics vs. Afterload Reduction for Treatment of HeartLogic Alerts","status":"RECRUITING","sponsor":"Heart Center Research, LLC","startDate":"2021-07-08","conditions":"Heart Failure, Congestive","enrollment":80},{"nctId":"NCT04919564","phase":"PHASE2","title":"Low Dose Continuous Furosemide Effect on Cardiac Surgery Patients With Kidney Dysfunction","status":"COMPLETED","sponsor":"National Cardiovascular Center Harapan Kita Hospital Indonesia","startDate":"2021-05-27","conditions":"Chronic Kidney Disease, Cardiac Disease","enrollment":90},{"nctId":"NCT02575963","phase":"PHASE1, PHASE2","title":"Lintuzumab-Ac225 in Older Acute Myeloid Leukemia (AML) Patients","status":"COMPLETED","sponsor":"Actinium Pharmaceuticals","startDate":"2012-10","conditions":"AML","enrollment":40},{"nctId":"NCT02649998","phase":"NA","title":"Short-term Efficacy of Furosemide, Isosorbide Dinitrate and Their Combination in ADHF","status":"WITHDRAWN","sponsor":"Chinese University of Hong Kong","startDate":"2017-01","conditions":"Heart Decompensation","enrollment":""},{"nctId":"NCT01030874","phase":"NA","title":"Orthostatic Hypotension Treatment on Rehab Unit","status":"COMPLETED","sponsor":"VA Office of Research and Development","startDate":"2011-10","conditions":"Orthostatic Hypotension, Falls","enrollment":356},{"nctId":"NCT04691687","phase":"PHASE4","title":"OUTpatient Intravenous LASix Trial in Reducing Hospitalization for Acute Decompensated Heart Failure","status":"COMPLETED","sponsor":"New York Presbyterian Brooklyn Methodist Hospital","startDate":"2012-05-01","conditions":"Heart Failure","enrollment":100},{"nctId":"NCT04679571","phase":"NA","title":"Efficacy of Targeted And Response-Guided Albumin Therapy Versus Standard Medical Treatment In Outcomes Of Recurrent Ascites In Patients With Decompensated Cirrhosis.","status":"UNKNOWN","sponsor":"Institute of Liver and Biliary Sciences, India","startDate":"2020-12-30","conditions":"Decompensated Cirrhosis","enrollment":100},{"nctId":"NCT03613779","phase":"NA","title":"CLUSTER-HF: Lung Ultrasound Guided Therapy in Heart Failure","status":"COMPLETED","sponsor":"Instituto Nacional de Cardiologia Ignacio Chavez","startDate":"2018-04-10","conditions":"Heart Failure","enrollment":130},{"nctId":"NCT00624650","phase":"PHASE2","title":"Hemodynamics and Extravascular Lung Water in Acute Lung Injury","status":"COMPLETED","sponsor":"Oregon Health and Science University","startDate":"2008-02","conditions":"Acute Lung Injury","enrollment":33},{"nctId":"NCT02767024","phase":"PHASE4","title":"Intravenous Vasodilator vs. Inotropic Therapy in Patients With Heart Failure","status":"WITHDRAWN","sponsor":"Montefiore Medical Center","startDate":"2018-05-01","conditions":"Acute Heart Failure","enrollment":""},{"nctId":"NCT00577135","phase":"PHASE3","title":"Determining Optimal Dose and Duration of Diuretic Treatment in People With Acute Heart Failure (The DOSE-AHF Study)","status":"COMPLETED","sponsor":"Duke University","startDate":"2008-02","conditions":"Heart Failure","enrollment":308},{"nctId":"NCT01140399","phase":"PHASE4","title":"REWORD-HF REverse WOrsening Renal Function in Decompensated Heart Failure","status":"TERMINATED","sponsor":"Niguarda Hospital","startDate":"2011-02","conditions":"Acute Decompensated Heart Failure","enrollment":10},{"nctId":"NCT01663662","phase":"PHASE4","title":"The Use of Tolvaptan to Prevent Renal Dysfunction in High Risk Patients With Heart Failure-Pilot Study","status":"WITHDRAWN","sponsor":"University of Michigan","startDate":"2012-08","conditions":"Heart Failure","enrollment":""},{"nctId":"NCT01945801","phase":"PHASE4","title":"Sodium-Restricted Diet and Diuretic in the Treatment of Severe Sleep Apnea","status":"COMPLETED","sponsor":"Hospital de Clinicas de Porto Alegre","startDate":"2013-10","conditions":"Obstructive Sleep Apnea","enrollment":54},{"nctId":"NCT01060293","phase":"PHASE4","title":"Dopamine in Acute Decompensated Heart Failure II","status":"TERMINATED","sponsor":"Larissa University Hospital","startDate":"2009-07","conditions":"Acute Decompensated Heart Failure","enrollment":161},{"nctId":"NCT00551122","phase":"PHASE1, PHASE2","title":"Gemcitabine, Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Progressive or Relapsed Metastatic Germ Cell Tumors","status":"UNKNOWN","sponsor":"University of Southampton","startDate":"2006-11","conditions":"Brain and Central Nervous System Tumors, Extragonadal Germ Cell Tumor, Ovarian Cancer","enrollment":23},{"nctId":"NCT01553513","phase":"","title":"PET/CT for the Quantification of Atherosclerotic Plaque Inflammation","status":"UNKNOWN","sponsor":"Ludwig-Maximilians - University of Munich","startDate":"2012-06","conditions":"Coronary Artery Disease, Acute Coronary Syndrome","enrollment":140},{"nctId":"NCT01028170","phase":"PHASE3","title":"Safety and Efficacy of Low Dose Hypertonic Saline Solution and High Dose Furosemide for Congestive Heart Failure","status":"COMPLETED","sponsor":"Aspirus Heart and Vascular Institute-Research and Education","startDate":"2009-11","conditions":"Congestive Heart Failure, Renal Insufficiency","enrollment":50},{"nctId":"NCT00937092","phase":"PHASE4","title":"Dopamine in Acute Decompensated Heart Failure (DAD-HF) Trial","status":"UNKNOWN","sponsor":"Larissa University Hospital","startDate":"2009-01","conditions":"Acute Heart Failure","enrollment":300}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":60,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Low-dose furosemide","genericName":"Low-dose furosemide","companyName":"Larissa University Hospital","companyId":"larissa-university-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Low-dose furosemide inhibits the Na-K-2Cl cotransporter in the thick ascending limb of the loop of Henle, reducing sodium reabsorption and promoting urinary sodium and water excretion. Used for Edema associated with congestive heart failure, Edema associated with hepatic cirrhosis, Edema associated with renal disease.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}