{"id":"low-dose-epinephrine-and-tranexamic-acid","safety":{"commonSideEffects":[{"rate":null,"effect":"Tachycardia"},{"rate":null,"effect":"Hypertension"},{"rate":null,"effect":"Arrhythmias"},{"rate":null,"effect":"Thrombotic events"},{"rate":null,"effect":"Nausea"}]},"_chembl":{"chemblId":"CHEMBL877","moleculeType":"Small molecule","molecularWeight":"157.21"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This combination leverages epinephrine's sympathomimetic effects to support cardiovascular function and perfusion, particularly in hemorrhagic or shock states. Tranexamic acid works by inhibiting plasminogen activation and plasmin activity, thereby stabilizing clot formation and reducing fibrin degradation. Together, they address both hemodynamic instability and excessive bleeding.","oneSentence":"Low-dose epinephrine stimulates adrenergic receptors to increase heart rate and blood pressure, while tranexamic acid inhibits fibrinolysis to reduce bleeding.","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:53:16.676Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute hemorrhage and hemorrhagic shock"},{"name":"Trauma-related bleeding"}]},"trialDetails":[{"nctId":"NCT07089251","phase":"PHASE4","title":"The Perioperative Outcome of Epinephrine Infusion and Tranexamic Acid in Knee Arthroplasty Surgery","status":"RECRUITING","sponsor":"King Abdullah International Medical Research Center","startDate":"2025-07-15","conditions":"Knee Arthroplasty, Total, Knee Arthritis, Osteoarthritis, Total Knee Anthroplasty","enrollment":80},{"nctId":"NCT02864095","phase":"NA","title":"The Effects of Low-dose Epinephrine Plus Tranexamic Acid on Perioperative Haemostasis and Inflammatory Reaction in Major Surgery","status":"UNKNOWN","sponsor":"Southwest Hospital, China","startDate":"2015-05","conditions":"Blood Loss","enrollment":200},{"nctId":"NCT02860221","phase":"NA","title":"Intravenous Versus Topical Administration of Low Dose Epinephrine Plus Combined Administration of Intravenous and Topical Tranexamic Acid (TXA)for Primary Total Knee Arthroplasty","status":"UNKNOWN","sponsor":"Southwest Hospital, China","startDate":"2015-05","conditions":"Blood Loss","enrollment":210}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"low-dose epinephrine and tranexamic acid","genericName":"low-dose epinephrine and tranexamic acid","companyName":"King Abdullah International Medical Research Center","companyId":"king-abdullah-international-medical-research-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Low-dose epinephrine stimulates adrenergic receptors to increase heart rate and blood pressure, while tranexamic acid inhibits fibrinolysis to reduce bleeding. Used for Acute hemorrhage and hemorrhagic shock, Trauma-related bleeding.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}