{"id":"low-dose-clomiphencitrat","safety":{"commonSideEffects":[{"rate":null,"effect":"Visual disturbances (blurred vision, scotomata)"},{"rate":null,"effect":"Hot flushes"},{"rate":null,"effect":"Mood changes"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Nausea"}]},"_chembl":{"chemblId":"CHEMBL2108580","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Clomiphene citrate competitively binds to estrogen receptors in the hypothalamus and pituitary gland, blocking the inhibitory effects of endogenous estrogen on gonadotropin-releasing hormone (GnRH) secretion. This disinhibition increases luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release, which in turn stimulates testicular testosterone production. At low doses, this approach preserves testicular function and fertility while raising testosterone levels.","oneSentence":"Low-dose clomiphene citrate acts as a selective estrogen receptor modulator (SERM) that blocks negative feedback on the hypothalamic-pituitary-gonadal axis, stimulating endogenous testosterone production in men.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:53:10.980Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Male hypogonadism with preserved or restored fertility"},{"name":"Testosterone replacement therapy alternative in men desiring fertility"}]},"trialDetails":[{"nctId":"NCT01577472","phase":"PHASE4","title":"Efficacy Study Comparing the Effect of Clomiphencitrate to an Antagonist Protocol","status":"COMPLETED","sponsor":"University Hospital, Basel, Switzerland","startDate":"2013-08","conditions":"Female Infertility, Ovarian Insufficiency","enrollment":117}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Low Dose Clomiphencitrat","genericName":"Low Dose Clomiphencitrat","companyName":"University Hospital, Basel, Switzerland","companyId":"university-hospital-basel-switzerland","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Low-dose clomiphene citrate acts as a selective estrogen receptor modulator that blocks negative feedback on the hypothalamic-pituitary-gonadal axis, stimulating endogenous testosterone production in men. Used for Male hypogonadism with preservation of fertility, Testosterone deficiency in men.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}