{"id":"low-dose-bisoprolol","safety":{"commonSideEffects":[{"rate":"10-15","effect":"Fatigue"},{"rate":"5-10","effect":"Dizziness"},{"rate":"5-10","effect":"Bradycardia"},{"rate":"5-10","effect":"Hypotension"},{"rate":"5-10","effect":"Headache"},{"rate":"2-5","effect":"Dyspnea"},{"rate":"2-5","effect":"Insomnia"}]},"_chembl":{"chemblId":"CHEMBL645","moleculeType":"Small molecule","molecularWeight":"325.45"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Bisoprolol selectively blocks beta-1 adrenergic receptors on cardiac tissue, decreasing heart contractility and heart rate, which reduces myocardial oxygen demand and lowers blood pressure. The low-dose formulation is designed to minimize systemic beta-blockade while maintaining cardioselective effects, making it suitable for patients requiring gentler hemodynamic modulation. This mechanism makes it effective for hypertension and heart failure management with reduced risk of bronchospasm compared to non-selective beta-blockers.","oneSentence":"Bisoprolol is a beta-1 selective adrenergic receptor antagonist that reduces heart rate and blood pressure by blocking the effects of catecholamines on the heart.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:53:09.982Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypertension"},{"name":"Chronic heart failure"},{"name":"Angina pectoris"},{"name":"Post-myocardial infarction"}]},"trialDetails":[{"nctId":"NCT07045038","phase":"NA","title":"Blood Flow Restricted Resistance Exercises Versus Low Level Laser on Cardiac Functions in Patients With Chronic Heart Failure","status":"ACTIVE_NOT_RECRUITING","sponsor":"Cairo University","startDate":"2025-01-20","conditions":"Heart Failure NYHA Class II","enrollment":60},{"nctId":"NCT06930092","phase":"NA","title":"RestoratIon of Myocardial Function by PeRcutaneous cOronary interVEntion in Patients With Ischemic CardioMyoPathy","status":"RECRUITING","sponsor":"Seoul National University Hospital","startDate":"2025-07-01","conditions":"Ischemic Cardiomyopathy","enrollment":158},{"nctId":"NCT03640312","phase":"PHASE2","title":"Efficacy and Safety of a Quadruple Ultra-low-dose Treatment for Hypertension","status":"COMPLETED","sponsor":"Washington University School of Medicine","startDate":"2019-08-30","conditions":"Hypertension","enrollment":62},{"nctId":"NCT01868880","phase":"PHASE4","title":"Effect of Ivabradine and Beta-blockers Combination Versus Beta-blockers Up-titration on Right Ventricular Pacing","status":"WITHDRAWN","sponsor":"Policlinico Casilino ASL RMB","startDate":"2016-02","conditions":"Heart Rate Control in ICD Patients With Heart Failure","enrollment":""},{"nctId":"NCT01074307","phase":"PHASE4","title":"A Prospective, Open-labeled, Multi-centric Trial in Subjects With Systolic Heart Failure to Evaluate Bisoprolol Treatment for the Effects on Surrogate Markers of Heart Failure in Korea","status":"COMPLETED","sponsor":"Merck KGaA, Darmstadt, Germany","startDate":"2009-10","conditions":"Heart Failure, Congestive","enrollment":180}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":17,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Concor"],"phase":"marketed","status":"active","brandName":"Low Dose Bisoprolol","genericName":"Low Dose Bisoprolol","companyName":"Merck KGaA, Darmstadt, Germany","companyId":"merck-kgaa-darmstadt-germany","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Bisoprolol is a selective beta-1 adrenergic receptor antagonist that reduces heart rate and blood pressure by blocking the effects of catecholamines on the heart. Used for Hypertension, Heart failure (systolic), Angina pectoris.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}