{"id":"low-dose-astragalus","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Allergic reaction (rare)"},{"rate":null,"effect":"Headache"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"Astragalus membranaceus root extract contains bioactive polysaccharides (astragalans) and saponins (astragalosides) that upregulate T-cell and macrophage function, increase cytokine production, and promote angiogenesis and collagen synthesis. At low doses, these constituents are thought to provide immunomodulatory and regenerative effects with reduced risk of over-stimulation. The mechanism is consistent with traditional Chinese medicine use as an immune tonic and tissue-healing agent.","oneSentence":"Low-dose Astragalus enhances immune function and promotes tissue repair through polysaccharide and saponin constituents that stimulate immune cell activity and growth factor production.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:19:32.162Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Immune support and enhancement"},{"name":"Tissue repair and wound healing"},{"name":"Fatigue and recovery (investigational)"}]},"trialDetails":[{"nctId":"NCT07417371","phase":"NA","title":"Study on the Mechanism of Pei Tu Ning Feng Tang in Alleviating Tourette Syndrome Via Functional Near-Infrared Spectroscopy (fNIRS) and the DA-MAPK-BDNF Pathway","status":"NOT_YET_RECRUITING","sponsor":"Dongdong Qin","startDate":"2026-04","conditions":"Tourette Syndrome in Children","enrollment":60},{"nctId":"NCT01720550","phase":"PHASE4","title":"PG2 Treatment for Improving Fatigue Among Advanced Cancer Patients Under Standard Palliative Care","status":"COMPLETED","sponsor":"PhytoHealth Corporation","startDate":"2012-11","conditions":"Cancer-related Fatigue","enrollment":323},{"nctId":"NCT03418779","phase":"PHASE2, PHASE3","title":"Treatment Effects of Chinese Medicine (Yi-Qi-Qing-Jie Herbal Compound) Combined With Immunosuppression Therapies in IgA Nephropathy Patients With High-risk of ESRD","status":"ACTIVE_NOT_RECRUITING","sponsor":"Guang'anmen Hospital of China Academy of Chinese Medical Sciences","startDate":"2019-07-04","conditions":"IgA Nephropathy at High Risk of Developing ESRD","enrollment":60},{"nctId":"NCT05647473","phase":"PHASE2","title":"Efficacy, Safety and Response Predictors of Adjuvant Astragalus for Cognition in Orthostatic Hypotension","status":"UNKNOWN","sponsor":"Fujian Medical University Union Hospital","startDate":"2024-02-20","conditions":"Orthostatic Hypotension, Alzheimer Disease","enrollment":66},{"nctId":"NCT06176599","phase":"NA","title":"Clinical Study on the Treatment of Diabetic Kidney Disease With Shenxiao Yuning Decoction With Syndrome of Qi and Yin Deficiency and Blood Stasis","status":"UNKNOWN","sponsor":"Lin Liao","startDate":"2022-09-01","conditions":"Diabetic Kidney Disease","enrollment":60},{"nctId":"NCT02189083","phase":"PHASE3","title":"Study of Tumor-shrinking Decoction (TSD) to Treat Symptomatic Uterine Fibroids","status":"COMPLETED","sponsor":"The University of Hong Kong","startDate":"2014-05","conditions":"Leiomyoma","enrollment":78},{"nctId":"NCT03591471","phase":"PHASE1, PHASE2","title":"Study on Children Henoch-Schönlein Purpura Nephritis With TCM Multistep Treatment","status":"UNKNOWN","sponsor":"Henan University of Traditional Chinese Medicine","startDate":"2014-09","conditions":"Henoch-Schönlein Purpura Nephritis","enrollment":500},{"nctId":"NCT01847807","phase":"PHASE3","title":"The Organ Protection of Astragalus in Subjects With Metabolic Syndrome","status":"COMPLETED","sponsor":"LanZhou University","startDate":"2011-01","conditions":"Metabolic Syndrome","enrollment":210}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"low dose Astragalus","genericName":"low dose Astragalus","companyName":"LanZhou University","companyId":"lanzhou-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Low-dose Astragalus enhances immune function and promotes tissue repair through polysaccharide and saponin constituents that stimulate immune cell activity and growth factor production. Used for Immune support and enhancement, Tissue repair and wound healing, Fatigue and recovery (investigational).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}