{"id":"lotrimin-ultra","safety":{"commonSideEffects":[{"rate":null,"effect":"Contact dermatitis"},{"rate":null,"effect":"Erythema"},{"rate":null,"effect":"Burning or stinging at application site"},{"rate":null,"effect":"Pruritus"}]},"_chembl":null,"_dailymed":{"setId":"9dfa08fb-0913-4326-b1eb-1425df6a2c82","title":"LOTRIMIN ULTRA JOCK ITCH (BUTENAFINE HYDROCHLORIDE) CREAM [BAYER HEALTHCARE LLC.]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Butenafine inhibits the enzyme squalene epoxidase, which is critical for ergosterol synthesis in fungal cell membranes. This leads to accumulation of squalene and depletion of ergosterol, destabilizing the fungal cell membrane and causing cell death. The drug is effective against dermatophytes, yeasts, and other fungi that cause superficial skin infections.","oneSentence":"Lotrimin Ultra contains butenafine, an allylamine antifungal that disrupts fungal cell membrane synthesis by inhibiting squalene epoxidase.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T04:14:12.906Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Tinea pedis (athlete's foot)"},{"name":"Tinea cruris (jock itch)"},{"name":"Tinea corporis (ringworm)"},{"name":"Tinea versicolor"}]},"trialDetails":[{"nctId":"NCT01580878","phase":"PHASE1","title":"Evaluate the Safety & Bioequivalence of a Generic Butenafine Cream & Lotrimin Ultra® & Compare Both to a Vehicle Control in Treatment of Interdigital Tinea Pedis","status":"COMPLETED","sponsor":"Sun Pharmaceutical Industries, Inc.","startDate":"2012-01","conditions":"Tinea Pedis","enrollment":707},{"nctId":"NCT01119742","phase":"PHASE1","title":"Clinical Equivalence of Two Generic Butenafine Hydrochloride 1% Creams as Compared to Lotrimin Ultra Cream in Patients With Interdigital Tinea Pedis","status":"TERMINATED","sponsor":"Sun Pharmaceutical Industries, Inc.","startDate":"2010-07","conditions":"Interdigital Tinea Pedis","enrollment":428}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Lotrimin Ultra®","genericName":"Lotrimin Ultra®","companyName":"Sun Pharmaceutical Industries, Inc.","companyId":"sun-pharmaceutical-industries-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Lotrimin Ultra contains butenafine, an allylamine antifungal that disrupts fungal cell membrane synthesis by inhibiting squalene epoxidase. Used for Tinea pedis (athlete's foot), Tinea cruris (jock itch), Tinea corporis (ringworm).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}