{"id":"losartan-amlodipine","safety":{"commonSideEffects":[{"rate":"5-10","effect":"Dizziness"},{"rate":"5-10","effect":"Headache"},{"rate":"3-7","effect":"Fatigue"},{"rate":"2-5","effect":"Peripheral edema"},{"rate":"1-3","effect":"Hyperkalemia"},{"rate":"1-2","effect":"Cough"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Losartan is an angiotensin II receptor blocker (ARB) that prevents angiotensin II from binding to AT1 receptors, reducing vasoconstriction and aldosterone secretion. Amlodipine is a dihydropyridine calcium channel blocker that inhibits calcium influx into vascular smooth muscle cells, causing vasodilation. Together, they provide complementary antihypertensive effects.","oneSentence":"This combination blocks angiotensin II receptors and calcium channels to reduce blood pressure through vasodilation and decreased vascular resistance.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:53:10.766Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypertension"}]},"trialDetails":[],"_emaApprovals":[],"_faersSignals":[{"count":1,"reaction":"ACUTE KIDNEY INJURY"},{"count":1,"reaction":"ADVERSE REACTION"},{"count":1,"reaction":"CHRONIC KIDNEY DISEASE"},{"count":1,"reaction":"DIZZINESS"},{"count":1,"reaction":"HYPERPARATHYROIDISM SECONDARY"},{"count":1,"reaction":"NAUSEA"},{"count":1,"reaction":"PYREXIA"},{"count":1,"reaction":"RENAL FAILURE"},{"count":1,"reaction":"STAPHYLOCOCCAL INFECTION"},{"count":1,"reaction":"SUICIDE ATTEMPT"}],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["COZAAR XQ™"],"phase":"marketed","status":"active","brandName":"Losartan (+) amlodipine","genericName":"Losartan (+) amlodipine","companyName":"Organon and Co","companyId":"organon-and-co","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination blocks angiotensin II receptors and calcium channels to reduce blood pressure through vasodilation and decreased vascular resistance. Used for Hypertension.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}