{"id":"lornoxicam","rwe":[],"tags":[{"label":"lornoxicam","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"M01AC05","category":"atc"},{"label":"Active","category":"status"},{"label":"Pain","category":"indication"},{"label":"Analgesics","category":"pharmacology"},{"label":"Analgesics, Non-Narcotic","category":"pharmacology"},{"label":"Anti-Inflammatory Agents","category":"pharmacology"},{"label":"Anti-Inflammatory Agents, Non-Steroidal","category":"pharmacology"},{"label":"Antirheumatic Agents","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Sensory System Agents","category":"pharmacology"}],"phase":"discontinued","safety":{"safetySignals":[{"llr":48.438,"date":"","count":36,"signal":"Drug interaction","source":"DrugCentral FAERS","actionTaken":"Reported 36 times (LLR=48)"},{"llr":44.855,"date":"","count":11,"signal":"Rebound effect","source":"DrugCentral FAERS","actionTaken":"Reported 11 times (LLR=45)"},{"llr":44.031,"date":"","count":19,"signal":"Angioedema","source":"DrugCentral FAERS","actionTaken":"Reported 19 times (LLR=44)"},{"llr":43.345,"date":"","count":6,"signal":"Tick-borne viral encephalitis","source":"DrugCentral FAERS","actionTaken":"Reported 6 times (LLR=43)"}],"commonSideEffects":[{"effect":"Drug interaction","drugRate":"LLR 48","severity":"common"},{"effect":"Rebound effect","drugRate":"LLR 45","severity":"common"},{"effect":"Angioedema","drugRate":"LLR 44","severity":"common"},{"effect":"Tick-borne viral encephalitis","drugRate":"LLR 43","severity":"common"}]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"lorcam","offLabel":[],"synonyms":["lornoxicam","chlortenoxicam","lorcam","xefocam"],"timeline":[],"approvals":[],"brandName":"Lorcam","ecosystem":[{"indication":"Pain","otherDrugs":[{"name":"acetylsalicylic acid","slug":"acetylsalicylic-acid","company":"Endo Pharms"},{"name":"bromfenac","slug":"bromfenac","company":"Bausch And Lomb Inc"},{"name":"butorphanol","slug":"butorphanol","company":""},{"name":"caffeine","slug":"caffeine","company":"Novartis"}],"globalPrevalence":1500000000}],"mechanism":{"modality":"Small Molecule","drugClass":"lornoxicam","explanation":"Imagine your body has a factory that produces chemicals called prostaglandins, which can cause pain and swelling. Lorcam blocks the machine that makes these chemicals, so the pain and swelling go away. This helps to relieve pain and reduce inflammation.","oneSentence":"Lorcam works by blocking the COX-2 enzyme, which reduces the production of prostaglandins that cause pain and inflammation.","technicalDetail":"Lorcam exerts its anti-inflammatory and analgesic effects by selectively inhibiting the activity of cyclooxygenase-2 (COX-2), a key enzyme involved in the conversion of arachidonic acid to prostaglandins."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1609","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=LORNOXICAM","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=LORNOXICAM","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T12:25:04.498302","biosimilars":[],"competitors":[{"drugName":"piroxicam","drugSlug":"piroxicam","fdaApproval":"1982-04-06","genericCount":18,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"meloxicam","drugSlug":"meloxicam","fdaApproval":"2000-04-13","patentExpiry":"May 26, 2030","patentStatus":"Patent 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University","startDate":"2022-07-20","conditions":["Pain, Acute","Edema","Trismus"],"enrollment":20,"completionDate":"2022-09-29"},{"nctId":"NCT04565093","phase":"NA","title":"Efficacy of iPACK After Unilateral TKA","status":"COMPLETED","sponsor":"King Khalid University Hospital","startDate":"2020-09-28","conditions":["Arthroplasty Complications","Pain, Joint","Arthritis Knee","Regional Anesthesia Morbidity"],"enrollment":80,"completionDate":"2021-03-27"},{"nctId":"NCT01718756","phase":"PHASE1,PHASE2","title":"Continuous Lornoxicam Infusion for Orthopaedic Surgery","status":"SUSPENDED","sponsor":"Mansoura University","startDate":"2013-06","conditions":["Closed Non Comminuted Long Bone Fractures"],"enrollment":96,"completionDate":"2022-02"},{"nctId":"NCT02698995","phase":"PHASE3","title":"Perineural Low-dose Dexamethasone Added to Infraclavicular Block Anesthesia","status":"COMPLETED","sponsor":"Foisor Orthopedics Clinical Hospital","startDate":"2015-11","conditions":["Postoperative Pain"],"enrollment":180,"completionDate":"2017-02"},{"nctId":"NCT03780556","phase":"NA","title":"Lornoxicam With Low Dose Ketamine Versus Pethidine to Control Pain of Acute Renal Colic","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2016-01-02","conditions":["Renal Colic"],"enrollment":120,"completionDate":"2018-05"},{"nctId":"NCT02749162","phase":"PHASE3","title":"Perineural Dexamethasone in Femural Nerve Block After Ligament Reconstruction","status":"COMPLETED","sponsor":"Foisor Orthopedics Clinical Hospital","startDate":"2015-11","conditions":["Postoperative Pain"],"enrollment":90,"completionDate":"2017-02"},{"nctId":"NCT03038321","phase":"PHASE4","title":"Solifenacin, Levofloxacin or Lornoxicam, Which Is Ideal for Management of Intravesical Instillation BCG Side Effects?","status":"UNKNOWN","sponsor":"Mansoura University","startDate":"2017-02-01","conditions":["Non-Muscle-invasive Bladder Cancer (NMIBC)","Bacillus Calmette-Guerin (BCG) Cystitis","Intra-vesical Instillation"],"enrollment":150,"completionDate":"2019-12"},{"nctId":"NCT01638962","phase":"NA","title":"The Effect on Knee Joint Loads of Analgesic Use Compared With Exercise in Patients With Knee Osteoarthritis - An RCT","status":"COMPLETED","sponsor":"University of Southern Denmark","startDate":"2012-08","conditions":["Osteoarthritis, Knee"],"enrollment":93,"completionDate":"2016-07"},{"nctId":"NCT02750917","phase":"PHASE3","title":"Lornoxicam Versus Etoricoxib in Postoperative Pain After Total Knee Arthroplasty","status":"COMPLETED","sponsor":"Foisor Orthopedics Clinical Hospital","startDate":"2014-09","conditions":["Postoperative Pain"],"enrollment":120,"completionDate":"2015-03"},{"nctId":"NCT02025166","phase":"NA","title":"Comparison Between Two Analgesic Methods for Pain Relief Following Surgical Abortion","status":"UNKNOWN","sponsor":"Rambam Health Care Campus","startDate":"2014-01","conditions":["Pain"],"enrollment":82,"completionDate":"2015-01"},{"nctId":"NCT01117948","phase":"PHASE2","title":"Efficacy and Safety of Lornoxicam in Patients With Mild to Moderate Probable Alzheimer´s Disease.","status":"TERMINATED","sponsor":"JSW Lifesciences","startDate":"2009-09","conditions":["Alzheimer´s Disease"],"enrollment":219,"completionDate":"2011-04"},{"nctId":"NCT01480752","phase":"PHASE2","title":"Reduction of Post-operative Endodontic Pain","status":"COMPLETED","sponsor":"Islamic Azad University, Sanandaj","startDate":"2011-09","conditions":["Post Operative Endodontic Pain"],"enrollment":60,"completionDate":"2012-12"},{"nctId":"NCT00293631","phase":"PHASE2","title":"Study of Lornoxicam or Ketorolac or Placebo for Post-Operative Pain After Bunionectomy","status":"COMPLETED","sponsor":"POZEN","startDate":"2005-11","conditions":["Bunionectomy","Orthopedic Surgery"],"enrollment":100,"completionDate":"2006-03"},{"nctId":"NCT00293657","phase":"PHASE2","title":"Study of Lornoxicam or Placebo for Acute Treatment of the Headache of Migraine.","status":"COMPLETED","sponsor":"POZEN","startDate":"2005-12","conditions":["Headache (Migraine)"],"enrollment":150,"completionDate":"2006-04"},{"nctId":"NCT01564680","phase":"PHASE4","title":"Lornoxicam vs. Paracetamol After Lower Abdominal Surgery","status":"COMPLETED","sponsor":"Imam Abdulrahman Bin Faisal University","startDate":"2009-03","conditions":["Postoperative Pain"],"enrollment":60,"completionDate":"2011-03"},{"nctId":"NCT01069055","phase":"PHASE3","title":"Comparison of Lornoxicam and Paracetamol for Pre-emptive Intravenous Analgesia for Elective Inguinal Hernia Repair","status":"UNKNOWN","sponsor":"Diskapi Teaching and Research Hospital","startDate":"2010-02","conditions":["Inguinal Hernia","Postoperative Pain"],"enrollment":60,"completionDate":"2010-06"},{"nctId":"NCT01055470","phase":"NA","title":"Comparative Clinical Trial of Lornoxicam to Diclofenac in Patients of Osteoarthritis of Knee Joint.","status":"COMPLETED","sponsor":"Government Medical College, Bhavnagar","startDate":"2008-12","conditions":["Osteoarthritis of Knee Joint"],"enrollment":40,"completionDate":"2009-06"},{"nctId":"NCT00997750","phase":"PHASE4","title":"Efficacy and Safety of Lornoxicam in Patients With Acute Coronary Syndrome","status":"COMPLETED","sponsor":"Central Clinical Hospital w/Outpatient Health Center of Business Administration for the President of Russian Federation","startDate":"2007-03","conditions":["Acute Coronary Syndrome"],"enrollment":85,"completionDate":"2009-06"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"007785","UNII":"ER09126G7A","CHEBI":"CHEBI:31783","INN_ID":"6233","RXNORM":"20890","UMLSCUI":"C0055477","ChEMBL_ID":"CHEMBL1569487","KEGG_DRUG":"D01866","DRUGBANK_ID":"DB06725","PUBCHEM_CID":"54690031","SNOMEDCT_US":"391655005","MESH_SUPPLEMENTAL_RECORD_UI":"C059451"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"pharmacokinetics":{"source":"DrugCentral","bioavailability":"1%","volumeOfDistribution":"0.143 L/kg"},"publicationCount":445,"therapeuticAreas":["Pain"],"atcClassification":{"source":"DrugCentral","atcCode":"M01AC05","allCodes":["M01AC05"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"discontinued","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Lorcam, also known as Lornoxicam, is a small molecule nonsteroidal anti-inflammatory drug (NSAID) of the oxicam class. It is used to treat pain, but its target is unknown. Lorcam is not FDA approved, and its commercial status is unclear. Key safety considerations include its low bioavailability of 1%, which may impact its efficacy. As a nonsteroidal anti-inflammatory drug, Lorcam works by inhibiting the enzyme COX-2, which is involved in the production of prostaglandins that cause pain and inflammation.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}