{"id":"loperamide-oxide","rwe":[{"pmid":"12917921","year":"2003","title":"Drug treatment for faecal incontinence in adults.","finding":"","journal":"The Cochrane database of systematic reviews","studyType":"Clinical Study"},{"pmid":"10947896","year":"2000","title":"Treatment of irritable bowel syndrome with loperamide oxide. 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By doing so, it helps to reduce diarrhea and other symptoms associated with irritable bowel syndrome (IBS). This is achieved by reducing the movement of food through the digestive system.","oneSentence":"Arestal works by binding to opioid receptors in the gut to slow down bowel movements.","technicalDetail":"Arestal, as a loperamide oxide, is believed to exert its effects by binding to mu-opioid receptors in the enteric nervous system, which slows down intestinal motility and increases water absorption."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1600","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=LOPERAMIDE%20OXIDE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=LOPERAMIDE 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Anderson Cancer Center","startDate":"2009-02-04","conditions":["Chemotherapeutic Agent Toxicity","Colorectal Cancer","Diarrhea"],"enrollment":100,"completionDate":"2014-08-12"},{"nctId":"NCT02018653","phase":"NA","title":"CASAD for Severe Diarrhea in the Emergency Department","status":"TERMINATED","sponsor":"M.D. Anderson Cancer Center","startDate":"2013-12","conditions":["Cancer","Diarrhea"],"enrollment":2,"completionDate":"2014-08"},{"nctId":"NCT02517957","phase":"PHASE2","title":"Xia Shi Surgical Treatment for Eczema Multi-center Clinical Research","status":"UNKNOWN","sponsor":"Shanghai Yueyang Integrated Medicine Hospital","startDate":"2015-08","conditions":["Eczema"],"enrollment":342,"completionDate":""},{"nctId":"NCT01780909","phase":"NA","title":"The Use of a Non-absorbable Marker for the Evaluation of the Gastrointestinal Transit","status":"UNKNOWN","sponsor":"KU Leuven","startDate":"2013-02","conditions":["Concentration-Time Profiles in Stomach & 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As a result, there is limited information available on its commercial status, safety considerations, or pharmacokinetic properties. Further research is needed to fully understand Arestal's characteristics and potential applications. Its development history is also unclear.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":false,"safety":true,"trials":true,"score":3}}