{"id":"loperamide-hydrochloride-simethicone-chewable-tablet","safety":{"commonSideEffects":[{"rate":"5-10%","effect":"Constipation"},{"rate":"1-5%","effect":"Dizziness"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"featherless-qwen","explanation":"Loperamide binds to μ-opioid receptors in the gastrointestinal tract, reducing peristalsis and increasing water absorption, which helps to alleviate diarrhea. Simethicone works by breaking up gas bubbles into smaller ones, making it easier for them to pass through the digestive system.","oneSentence":"Loperamide hydrochloride acts on opioid receptors in the gut to slow down intestinal motility, while simethicone reduces surface tension in gas bubbles to facilitate their elimination.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:19:25.175Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Symptomatic relief of diarrhea, including traveler's diarrhea and acute nonspecific diarrhea"},{"name":"Relief of bloating and discomfort associated with excess gas"}]},"trialDetails":[{"nctId":"NCT02340481","phase":"PHASE3","title":"Efficacy and Safety Study of Loperamide Hydrochloride/Simethicone Chewable Tablet in Treatment of Acute Diarrhea With Abdominal Discomfort and Flatulence","status":"COMPLETED","sponsor":"Xian-Janssen Pharmaceutical Ltd.","startDate":"2005-07","conditions":"Diarrhea","enrollment":217}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Loperamide hydrochloride + simethicone chewable tablet","genericName":"Loperamide hydrochloride + simethicone chewable tablet","companyName":"Xian-Janssen Pharmaceutical Ltd.","companyId":"xian-janssen-pharmaceutical-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Loperamide hydrochloride acts on opioid receptors in the gut to slow down intestinal motility, while simethicone reduces surface tension in gas bubbles to facilitate their elimination. Used for Symptomatic relief of diarrhea, including traveler's diarrhea and acute nonspecific diarrhea, Relief of bloating and discomfort associated with excess gas.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}