{"id":"long-lasting-injectable-naltrexone","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site reactions"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Fatigue"},{"rate":null,"effect":"Hepatotoxicity (at high doses)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Naltrexone competitively binds to opioid receptors (mu, delta, and kappa) in the central nervous system, preventing opioid agonists from activating these receptors. The long-acting injectable formulation provides sustained drug levels over weeks to months, improving medication adherence and reducing relapse risk in opioid use disorder by maintaining continuous receptor blockade.","oneSentence":"Naltrexone is an opioid receptor antagonist that blocks the effects of opioids and reduces cravings for opioid use.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:52:59.105Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Opioid use disorder (prevention of relapse)"},{"name":"Alcohol use disorder"}]},"trialDetails":[{"nctId":"NCT00453609","phase":"PHASE4","title":"Injectable Naltrexone Treatment of Alcohol Dependence in Serious Mental Illness (SMI)","status":"COMPLETED","sponsor":"State University of New York - Upstate Medical University","startDate":"2007-04","conditions":"Schizophrenia, Schizoaffective Disorder, Bipolar Disorder","enrollment":15}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"long-lasting injectable naltrexone","genericName":"long-lasting injectable naltrexone","companyName":"State University of New York - Upstate Medical University","companyId":"state-university-of-new-york-upstate-medical-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Naltrexone is an opioid receptor antagonist that blocks the effects of opioids and reduces cravings for opioid use. Used for Opioid use disorder (prevention of relapse), Alcohol use disorder.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}