{"id":"locobase-repair","safety":{"commonSideEffects":[{"rate":null,"effect":"Local skin irritation"},{"rate":null,"effect":"Contact sensitization"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Locobase® REPAIR is a topical formulation designed to repair and maintain the skin barrier function in dry and damaged skin conditions. It combines emollients and occlusives to reduce transepidermal water loss and restore skin hydration. The product is intended for symptomatic relief of dry skin and support of skin barrier recovery.","oneSentence":"Locobase® REPAIR is an emollient and skin barrier repair product that restores skin hydration and protects damaged skin through occlusive and humectant ingredients.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:52:49.143Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Dry skin and skin barrier dysfunction"},{"name":"Symptomatic relief of xerosis and atopic dermatitis-prone skin"}]},"trialDetails":[{"nctId":"NCT00673725","phase":"PHASE4","title":"Locobase® REPAIR Used as an Adjunctive to Standard Therapy in Children With Moderate to Severe Atopic Dermatitis","status":"COMPLETED","sponsor":"Astellas Pharma Europe B.V.","startDate":"2008-03","conditions":"Dermatitis, Atopic","enrollment":49}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Locobase® REPAIR","genericName":"Locobase® REPAIR","companyName":"Astellas Pharma Europe B.V.","companyId":"astellas-pharma-europe-b-v","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Locobase® REPAIR is an emollient and skin barrier repair product that restores skin hydration and protects damaged skin through occlusive and humectant ingredients. Used for Dry skin and skin barrier dysfunction, Symptomatic relief of xerosis and atopic dermatitis-prone skin.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}