{"id":"loceryl-nl-cosmetic-varnish","safety":{"commonSideEffects":[{"rate":null,"effect":"Local irritation or burning at application site"},{"rate":null,"effect":"Nail discoloration or discomfort"},{"rate":null,"effect":"Allergic contact dermatitis"}]},"_chembl":{"chemblId":"CHEMBL392414","moleculeType":"Small molecule","molecularWeight":"1123.33"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"By disrupting ergosterol production in fungal cell membranes, amorolfine compromises membrane integrity and function, leading to fungal cell death. The cosmetic varnish formulation provides a protective, occlusive barrier that enhances drug penetration into infected nail tissue while improving cosmetic appearance during treatment.","oneSentence":"Amorolfine is a morpholine antifungal that inhibits fungal sterol synthesis by blocking both Δ14-reductase and Δ8-Δ7-isomerase enzymes in the ergosterol biosynthesis pathway.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:52:43.355Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Onychomycosis (fungal nail infection)"}]},"trialDetails":[{"nctId":"NCT02321098","phase":"PHASE4","title":"Antifungal Activity of Loceryl Nail Lacquer in Combination With a Cosmetic Varnish","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2014-02","conditions":"Foot Dermatoses","enrollment":50}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Loceryl NL + Cosmetic varnish","genericName":"Loceryl NL + Cosmetic varnish","companyName":"Galderma R&D","companyId":"galderma-r-d","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Amorolfine is a morpholine antifungal that inhibits fungal sterol synthesis by blocking both Δ14-reductase and Δ8→Δ7-isomerase enzymes in the ergosterol biosynthesis pathway. Used for Onychomycosis (fungal nail infection).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}