{"id":"loceryl-nl-15-months","safety":{"commonSideEffects":[{"rate":null,"effect":"Nail discoloration or discoloured nails"},{"rate":null,"effect":"Periungual erythema"},{"rate":null,"effect":"Local irritation at application site"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"By disrupting ergosterol production in fungal cell membranes, amorolfine compromises membrane integrity and function, leading to fungal cell death. This dual-enzyme inhibition makes it effective against a broad spectrum of dermatophytes, yeasts, and non-dermatophyte molds. The 15-month nail lacquer formulation provides sustained local delivery to treat onychomycosis (fungal nail infections).","oneSentence":"Amorolfine is a morpholine antifungal that inhibits fungal sterol synthesis by blocking both Δ14-reductase and Δ8-Δ7-isomerase enzymes in the ergosterol biosynthesis pathway.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:52:52.757Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Onychomycosis (fungal nail infection) of toenails and fingernails"}]},"trialDetails":[{"nctId":"NCT02321098","phase":"PHASE4","title":"Antifungal Activity of Loceryl Nail Lacquer in Combination With a Cosmetic Varnish","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2014-02","conditions":"Foot Dermatoses","enrollment":50}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Loceryl NL 15 months","genericName":"Loceryl NL 15 months","companyName":"Galderma R&D","companyId":"galderma-r-d","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Loceryl is an antifungal nail lacquer that inhibits fungal cell wall synthesis by disrupting ergosterol production. Used for Onychomycosis (fungal nail infection).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}