{"id":"loceryl-nl","safety":{"commonSideEffects":[{"rate":null,"effect":"Nail discoloration"},{"rate":null,"effect":"Nail brittleness"},{"rate":null,"effect":"Local irritation at application site"},{"rate":null,"effect":"Periungual erythema"}]},"_chembl":{"chemblId":"CHEMBL392414","moleculeType":"Small molecule","molecularWeight":"1123.33"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Amorolfine, the active ingredient in Loceryl, is a morpholine antifungal that inhibits sterol 14α-demethylase, a key enzyme in fungal ergosterol biosynthesis. By disrupting ergosterol production, the drug compromises fungal cell membrane integrity, leading to fungal cell death. It is applied topically as a nail lacquer for direct delivery to infected nail tissue.","oneSentence":"Loceryl is an antifungal nail lacquer that inhibits fungal cell wall synthesis by disrupting ergosterol production.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:52:40.751Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Onychomycosis (fungal nail infection)"}]},"trialDetails":[{"nctId":"NCT02321098","phase":"PHASE4","title":"Antifungal Activity of Loceryl Nail Lacquer in Combination With a Cosmetic Varnish","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2014-02","conditions":"Foot Dermatoses","enrollment":50},{"nctId":"NCT02679911","phase":"PHASE4","title":"Treatment of Onychomycosis With Loceryl (Amorolfine) Nail Lacquer 5% Versus Ciclopirox Nail Lacquer","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2015-09","conditions":"Foot Dermatoses","enrollment":20},{"nctId":"NCT02705664","phase":"PHASE4","title":"Treatment of Onychomycosis With Loceryl (Amorolfine) Nail Lacquer 5% Versus a Two-course Treatment With Urea 40% Ointment and Bifonazole Cream 1%","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2016-01","conditions":"Foot Dermatoses","enrollment":22}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Loceryl Nail Lacquer"],"phase":"marketed","status":"active","brandName":"Loceryl NL","genericName":"Loceryl NL","companyName":"Galderma R&D","companyId":"galderma-r-d","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Loceryl is an antifungal nail lacquer that inhibits fungal cell wall synthesis by disrupting ergosterol production. Used for Onychomycosis (fungal nail infection).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}