{"id":"local-anesthetic-injection-of-cpl-01","safety":{"commonSideEffects":[{"rate":null,"effect":"Local injection site reactions"},{"rate":null,"effect":"Systemic toxicity (if absorbed)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"As a local anesthetic, CPL-01 works by inhibiting sodium channel activity in nerve fibers, preventing the generation and propagation of action potentials in sensory and motor neurons. This results in reversible loss of sensation and motor function in the localized area of administration. The drug is designed for direct injection into tissues requiring anesthesia.","oneSentence":"CPL-01 is a local anesthetic injection that blocks nerve conduction to provide localized pain relief and anesthesia at the injection site.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:19:16.159Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Local anesthesia for injection (specific indication not publicly detailed)"}]},"trialDetails":[{"nctId":"NCT05831449","phase":"PHASE3","title":"CPL-01 in the Management of Postoperative Pain After Bunionectomy","status":"COMPLETED","sponsor":"Cali Pharmaceuticals LLC","startDate":"2023-05-22","conditions":"Bunion","enrollment":616},{"nctId":"NCT05813847","phase":"PHASE3","title":"Herniorrhaphy for Postoperative Pain","status":"COMPLETED","sponsor":"Cali Pharmaceuticals LLC","startDate":"2023-04-18","conditions":"Hernia, Inguinal","enrollment":518}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["CPL-01","Long-acting ropivacaine"],"phase":"phase_3","status":"active","brandName":"Local anesthetic injection of CPL-01","genericName":"Local anesthetic injection of CPL-01","companyName":"Cali Pharmaceuticals LLC","companyId":"cali-pharmaceuticals-llc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"CPL-01 is a local anesthetic injection that blocks nerve conduction to provide localized pain relief and anesthesia at the injection site. Used for Local anesthesia for injection (specific indication not publicly detailed).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}