{"id":"loading-bolus-of-cefoxitin","safety":{"commonSideEffects":[{"rate":"1-3","effect":"Hypersensitivity reactions (rash, urticaria)"},{"rate":"1-2","effect":"Diarrhea"},{"rate":"1-2","effect":"Phlebitis at injection site"},{"rate":"0.5-1","effect":"Nausea"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Cefoxitin works by disrupting the cross-linking of peptidoglycan in bacterial cell walls, leading to cell wall instability and bacterial death. It has broad-spectrum activity against gram-positive and gram-negative bacteria, including anaerobes, making it useful for surgical prophylaxis and mixed infections. A loading bolus provides rapid achievement of therapeutic concentrations.","oneSentence":"Cefoxitin is a second-generation cephalosporin antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:19:16.151Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Surgical site infection prophylaxis"},{"name":"Mixed aerobic-anaerobic infections"},{"name":"Intra-abdominal infections"}]},"trialDetails":[{"nctId":"NCT05755789","phase":"PHASE3","title":"Intermittent Cefoxitin Administration Versus Loading Bolus Followed by Continuous Infusion for the Prevention of Surgical Site Infection in Colorectal Surgery","status":"RECRUITING","sponsor":"Poitiers University Hospital","startDate":"2023-06-22","conditions":"Antibiotic Prophylaxis, Colorectal Surgery","enrollment":2000}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Loading bolus of cefoxitin","genericName":"Loading bolus of cefoxitin","companyName":"Poitiers University Hospital","companyId":"poitiers-university-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Cefoxitin is a second-generation cephalosporin antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins. Used for Surgical site infection prophylaxis, Mixed aerobic-anaerobic infections, Intra-abdominal infections.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}