{"id":"lng-ius-bay-86-5028","safety":{"commonSideEffects":[{"rate":"20-30","effect":"Irregular bleeding or amenorrhea"},{"rate":"5-15","effect":"Abdominal/pelvic pain"},{"rate":"5-10","effect":"Headache"},{"rate":"5-10","effect":"Breast tenderness"},{"rate":"2-5","effect":"Device expulsion"},{"rate":"<1","effect":"Perforation (rare)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The device releases levonorgestrel (a synthetic progestin) in small amounts directly into the uterine cavity over an extended period. This creates a local contraceptive effect through multiple mechanisms: thickening cervical mucus to impede sperm transport, altering the endometrium to prevent implantation, and suppressing ovulation in some cycles. The localized delivery minimizes systemic hormone exposure compared to oral contraceptives.","oneSentence":"LNG-IUS is a levonorgestrel-releasing intrauterine system that provides long-acting reversible contraception by releasing a synthetic progestin directly into the uterus.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:49:34.012Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Contraception (long-acting reversible)"},{"name":"Heavy menstrual bleeding (off-label/secondary indication)"}]},"trialDetails":[{"nctId":"NCT01397097","phase":"PHASE3","title":"LCS12 vs. ENG Subdermal Implant (Nexplanon) Discontinuation Rate Study","status":"COMPLETED","sponsor":"Bayer","startDate":"2011-09","conditions":"Contraception","enrollment":766}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"LNG-IUS (BAY 86-5028)","genericName":"LNG-IUS (BAY 86-5028)","companyName":"Bayer","companyId":"bayer","modality":"Small molecule","firstApprovalDate":"","aiSummary":"LNG-IUS is a levonorgestrel-releasing intrauterine system that provides long-acting reversible contraception by releasing a synthetic progestin directly into the uterus. Used for Contraception (long-acting reversible), Heavy menstrual bleeding (off-label/secondary indication).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}