{"id":"lmwh-folic-acid","safety":{"commonSideEffects":[{"rate":null,"effect":"Bleeding"},{"rate":null,"effect":"Thrombocytopenia"},{"rate":null,"effect":"Injection site reactions"},{"rate":null,"effect":"Gastrointestinal upset (folic acid)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"LMWH inhibits thrombin and Factor Xa, preventing thrombosis through anticoagulation. Folic acid is a B vitamin essential for DNA synthesis and homocysteine metabolism, potentially reducing cardiovascular risk. The combination may be used in pregnancy or thrombophilic conditions where both anticoagulation and folate supplementation are therapeutically beneficial.","oneSentence":"This combination product uses low-molecular-weight heparin (LMWH) to prevent blood clots and folic acid to support cellular function and reduce homocysteine levels.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:41:17.833Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Thromboprophylaxis in pregnancy or thrombophilic disorders"},{"name":"Prevention of venous thromboembolism with folate supplementation"}]},"trialDetails":[{"nctId":"NCT03792997","phase":"PHASE2","title":"A Therapeutic Protocol in Previous Failed ART Patients With High Total NK Cells","status":"COMPLETED","sponsor":"Benha University","startDate":"2019-01-01","conditions":"Unexplained Infertility","enrollment":100},{"nctId":"NCT01608347","phase":"PHASE4","title":"Low Molecular Weight Heparin in Recurrent Miscarriage With Negative Antiphospholipid Antibodies","status":"COMPLETED","sponsor":"Omar Mamdouh Shaaban","startDate":"2010-01","conditions":"Recurrent Miscarriage","enrollment":228},{"nctId":"NCT00785421","phase":"PHASE2, PHASE3","title":"Chemotherapy With or Without Enoxaparin in Pancreatic Cancer","status":"COMPLETED","sponsor":"CONKO-Studiengruppe","startDate":"2004-04","conditions":"Pancreatic Cancer","enrollment":312},{"nctId":"NCT00400387","phase":"PHASE3","title":"Effectiveness of Dalteparin Therapy as Intervention in Recurrent Pregnancy Loss","status":"COMPLETED","sponsor":"University of Jena","startDate":"2006-11","conditions":"Abortion, Habitual","enrollment":449},{"nctId":"NCT00323011","phase":"PHASE2","title":"FOLFIRI + Bevacizumab With or Without Dalteparin in First Line Treatment of Advanced Colorectal Cancer","status":"TERMINATED","sponsor":"University of Southern California","startDate":"2006-05","conditions":"Colorectal Cancer","enrollment":5},{"nctId":"NCT01945879","phase":"PHASE1, PHASE2","title":"Pilot Safety Trial of Chemotherapy and Use of Heparin in Patients With Pancreatic Cancer","status":"COMPLETED","sponsor":"CONKO-Studiengruppe","startDate":"2003-01","conditions":"Pancreatic Cancer","enrollment":19},{"nctId":"NCT01281800","phase":"PHASE2","title":"Cisplatin With Alimta or Gemcitabine in Long Infusion for Mesothelioma","status":"UNKNOWN","sponsor":"Institute of Oncology Ljubljana","startDate":"2008-08","conditions":"Mesothelioma","enrollment":72}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2107265,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["(Clexane, Sanofi Aventis, Paris, France)"],"phase":"marketed","status":"active","brandName":"LMWH+Folic acid","genericName":"LMWH+Folic acid","companyName":"Omar Mamdouh Shaaban","companyId":"omar-mamdouh-shaaban","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination product uses low-molecular-weight heparin (LMWH) to prevent blood clots and folic acid to support cellular function and reduce homocysteine levels. Used for Thromboprophylaxis in pregnancy or thrombophilic disorders, Prevention of venous thromboembolism with folate supplementation.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}