{"id":"live-sk08-powder","safety":{"commonSideEffects":[{"rate":null,"effect":"Mild gastrointestinal symptoms"},{"rate":null,"effect":"Local or systemic inflammatory response"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"As a live vaccine formulation, SK08 likely works by introducing a weakened or modified form of a pathogenic organism to prime the adaptive immune system, generating both cellular and humoral immunity. The powder formulation suggests oral or mucosal administration to establish local and systemic immune protection. The specific pathogen or therapeutic target remains proprietary to the developer.","oneSentence":"Live SK08 powder is a live attenuated bacterial vaccine designed to stimulate immune responses against specific pathogens or disease targets.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:19:08.403Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Indication under investigation in Phase 3 (specific indication not publicly disclosed)"}]},"trialDetails":[{"nctId":"NCT06247046","phase":"PHASE3","title":"A Study to Evaluate the Efficacy and Safety of Live SK08 Powder in Patients With IBS-D","status":"RECRUITING","sponsor":"Guangzhou Zhiyi Biotechnology Co., Ltd.","startDate":"2024-03-16","conditions":"Irritable Bowel Syndrome With Diarrhea","enrollment":1298},{"nctId":"NCT06725017","phase":"PHASE2","title":"A Phase 2 Study to Evaluate the Efficacy and Safety of Live SK08 Powder in Adult Patients with Active Mild to Moderate Ulcerative Colitis","status":"NOT_YET_RECRUITING","sponsor":"Guangzhou Zhiyi Biotechnology Co., Ltd.","startDate":"2025-07-01","conditions":"Ulcerative Colitis (UC)","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Live SK08 powder","genericName":"Live SK08 powder","companyName":"Guangzhou Zhiyi Biotechnology Co., Ltd.","companyId":"guangzhou-zhiyi-biotechnology-co-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Live SK08 powder is a live attenuated bacterial vaccine designed to stimulate immune responses against specific pathogens or disease targets. Used for Indication under investigation in Phase 3 (specific indication not publicly disclosed).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}