{"id":"live-attenuated-sa-14-14-2-vaccine","safety":{"commonSideEffects":[{"rate":null,"effect":"Fever"},{"rate":null,"effect":"Injection site reactions"},{"rate":null,"effect":"Myalgia"},{"rate":null,"effect":"Headache"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"SA 14-14-2 is a live attenuated strain of Japanese encephalitis virus (JEV) derived from the wild-type SA 14 strain through serial passage. The vaccine replicates in vaccinated individuals but causes minimal or no disease, triggering both humoral and cellular immune responses that provide protection against natural JEV infection. This approach leverages the immunogenicity of live virus while maintaining safety through attenuation.","oneSentence":"A live attenuated Japanese encephalitis virus vaccine that stimulates immune responses against Japanese encephalitis virus through controlled viral replication.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:49:33.027Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Japanese encephalitis prevention"}]},"trialDetails":[{"nctId":"NCT02880865","phase":"PHASE4","title":"Immunogenicity and Safety of Japanese Encephalitis Vaccine When Given With Measles-Mumps-Rubella (MMR) Vaccine","status":"COMPLETED","sponsor":"PATH","startDate":"2016-10-13","conditions":"Encephalitis, Japanese, Measles, Mumps","enrollment":628},{"nctId":"NCT00463476","phase":"PHASE4","title":"Boosterability of Live Attenuated Japanese Encephalitis (JE) Vaccine in Children Who Have Previously Received Inactivated JE Vaccine","status":"COMPLETED","sponsor":"PATH","startDate":"2007-07-09","conditions":"Japanese Encephalitis","enrollment":305},{"nctId":"NCT00249769","phase":"PHASE3","title":"Determining Safety and Efficacy of Japanese Encephalitis Vaccine When Given With Measles Vaccine","status":"COMPLETED","sponsor":"PATH","startDate":"2005-11-21","conditions":"Encephalitis, Japanese B","enrollment":600},{"nctId":"NCT00463684","phase":"PHASE4","title":"Live Attenuated Japanese Encephalitis (JE) Vaccine Coadministered With Measles Vaccine in Infants 9 Months of Age","status":"COMPLETED","sponsor":"PATH","startDate":"2007-07-07","conditions":"Japanese Encephalitis","enrollment":278},{"nctId":"NCT01567865","phase":"PHASE4","title":"Lot-to-lot Consistency Trial of Japanese Encephalitis Live Attenuated SA 14-14-2 Vaccine","status":"COMPLETED","sponsor":"PATH","startDate":"2012-05","conditions":"Japanese Encephalitis","enrollment":818},{"nctId":"NCT01635816","phase":"PHASE4","title":"Immunogenicity of SA 14-14-2 JE Vaccine","status":"COMPLETED","sponsor":"International Centre for Diarrhoeal Disease Research, Bangladesh","startDate":"2012-05","conditions":"Healthy Infants","enrollment":1000},{"nctId":"NCT00412516","phase":"PHASE3","title":"Determining Long-Term Safety and Efficacy of Japanese Encephalitis Vaccine When Given With Measles Vaccine","status":"COMPLETED","sponsor":"PATH","startDate":"2006-12","conditions":"Encephalitis, Japanese B","enrollment":519}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":10,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Live attenuated SA 14-14-2 vaccine","genericName":"Live attenuated SA 14-14-2 vaccine","companyName":"PATH","companyId":"path","modality":"Biologic","firstApprovalDate":"","aiSummary":"A live attenuated Japanese encephalitis virus vaccine that stimulates immune responses against Japanese encephalitis virus through controlled viral replication. Used for Japanese encephalitis prevention.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}