{"id":"live-attenuated-human-rotavirus-vaccine","safety":{"commonSideEffects":[{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Vomiting"},{"rate":null,"effect":"Fever"},{"rate":null,"effect":"Irritability"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The vaccine contains a live but weakened (attenuated) rotavirus strain that replicates in the intestinal tract without causing severe disease. This triggers both humoral (antibody) and cell-mediated immune responses, priming the immune system to recognize and neutralize wild-type rotavirus upon natural exposure. The attenuated virus is designed to be immunogenic while maintaining a safety profile suitable for infants.","oneSentence":"A live attenuated rotavirus vaccine stimulates the immune system to produce antibodies and cellular immunity against rotavirus by introducing a weakened form of the virus.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:49:33.024Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of rotavirus gastroenteritis in infants and young children"}]},"trialDetails":[{"nctId":"NCT06331156","phase":"PHASE3","title":"A Study on the Immune Response and Safety of Inactivated Poliovirus Vaccine (IPV) When Co-administered With Human Rotavirus (HRV) Porcine Circovirus (PCV)-Free Vaccine in Healthy Chinese Infants","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2024-03-22","conditions":"Gastroenteritis","enrollment":400},{"nctId":"NCT04429295","phase":"PHASE3","title":"Study of DTwP-HepB-Hib-IPV (SHAN6™) Vaccine 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Used for Prevention of rotavirus gastroenteritis in infants and young children.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}