{"id":"lithium-fluvoxamine","safety":{"commonSideEffects":[{"rate":null,"effect":"Tremor"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Polyuria/polydipsia"},{"rate":null,"effect":"Sedation"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Serotonin syndrome (rare)"}]},"_chembl":{"chemblId":"CHEMBL814","moleculeType":"Small molecule","molecularWeight":"318.34"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Lithium modulates second-messenger systems (particularly inositol phosphate metabolism) and protein kinase C signaling, providing mood-stabilizing effects. Fluvoxamine is a selective serotonin reuptake inhibitor (SSRI) that increases synaptic serotonin concentration. The combination is used to enhance efficacy in treatment-resistant depression and bipolar disorder by addressing both monoaminergic and intracellular signaling mechanisms.","oneSentence":"Lithium enhances mood stabilization through effects on intracellular signaling, while fluvoxamine increases serotonin availability by inhibiting its reuptake, together targeting mood disorders through complementary neurochemical pathways.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:52:40.145Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Treatment-resistant depression"},{"name":"Bipolar disorder (depression phase)"},{"name":"Major depressive disorder with augmentation"}]},"trialDetails":[{"nctId":"NCT02893371","phase":"","title":"Longitudinal Comparative Effectiveness of Bipolar Disorder Therapies","status":"TERMINATED","sponsor":"University of New Mexico","startDate":"2016-09","conditions":"Bipolar Disorder","enrollment":1037352},{"nctId":"NCT02374567","phase":"PHASE3","title":"Pharmacovigilance in Gerontopsychiatric Patients","status":"TERMINATED","sponsor":"Hannover Medical School","startDate":"2015-01","conditions":"Dementia, Depression, Schizophrenia","enrollment":407},{"nctId":"NCT03219008","phase":"PHASE4","title":"Multi-Dimensional Diagnosis,Individualized Therapy,and Management Technique for Major Depressive Disorder:Based on Clinical and Pathological Characteristics","status":"UNKNOWN","sponsor":"Shanghai Mental Health Center","startDate":"2017-08-01","conditions":"Depressive Disorder","enrollment":800},{"nctId":"NCT01896349","phase":"NA","title":"Interpersonal Psychotherapy for Treatment Resistant Depression","status":"UNKNOWN","sponsor":"Hospital de Clinicas de Porto Alegre","startDate":"2013-04","conditions":"Treatment Resistant Depression","enrollment":74},{"nctId":"NCT00704860","phase":"PHASE4","title":"Treatment-Resistant Depression, Hippocampus Atrophy and Serotonin Genetic Polymorphism","status":"COMPLETED","sponsor":"University of Ottawa","startDate":"2005-02","conditions":"Major Depression","enrollment":27}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Lithium+fluvoxamine","genericName":"Lithium+fluvoxamine","companyName":"Shanghai Mental Health Center","companyId":"shanghai-mental-health-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Lithium enhances mood stabilization through effects on intracellular signaling, while fluvoxamine increases serotonin availability by inhibiting its reuptake, together targeting both bipolar disorder and depression. Used for Bipolar disorder depression, Treatment-resistant depression, Major depressive disorder with bipolar features.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}