{"id":"lithium-fluoxetine","safety":{"commonSideEffects":[{"rate":"10-25","effect":"Tremor"},{"rate":"15-30","effect":"Nausea"},{"rate":"10-20","effect":"Diarrhea"},{"rate":"20-40","effect":"Polyuria/polydipsia"},{"rate":"10-15","effect":"Weight gain"},{"rate":"10-20","effect":"Sexual dysfunction"},{"rate":"10-15","effect":"Headache"},{"rate":"<1","effect":"Serotonin syndrome (rare)"}]},"_chembl":{"chemblId":"CHEMBL1201082","moleculeType":"Small molecule","molecularWeight":"345.79"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Lithium modulates intracellular signaling pathways and reduces inositol recycling, potentiating serotonergic neurotransmission. Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) that prevents serotonin reabsorption at the synapse. The combination is used clinically to enhance antidepressant efficacy in treatment-resistant depression by synergistic augmentation of serotonergic signaling.","oneSentence":"Lithium enhances serotonergic neurotransmission by inhibiting inositol monophosphatase while fluoxetine blocks serotonin reuptake, together augmenting central serotonergic activity for mood stabilization and antidepressant effects.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:52:34.624Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Major depressive disorder, treatment-resistant"},{"name":"Bipolar disorder depression"}]},"trialDetails":[{"nctId":"NCT05814640","phase":"PHASE1, PHASE2","title":"Sequenced Treatment Alternatives to Relieve Adolescent Depression (STAR-AD)","status":"RECRUITING","sponsor":"First Affiliated Hospital of Chongqing Medical University","startDate":"2023-02-20","conditions":"Depression, 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and antidepressant effects. Used for Major depressive disorder, treatment-resistant, Bipolar disorder depression.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}