{"id":"listerine-cool-mint-antiseptic-mouthwash","safety":{"commonSideEffects":[{"rate":null,"effect":"Oral irritation or burning sensation"},{"rate":null,"effect":"Tooth staining (with prolonged use)"},{"rate":null,"effect":"Allergic reaction (rare)"}]},"_chembl":{"chemblId":"CHEMBL4298044","moleculeType":"Unknown"},"_dailymed":{"setId":"44f2b66a-26ae-1044-e063-6394a90a9ab6","title":"LISTERINE COOL MINT INTENSE ANTISEPTIC ANTIGINGIVITIS/ ANTIPLAQUE MOUTHWASH (EUCALYPTOL, MENTHOL, METHYL SALICYLATE, THYMOL) MOUTHWASH [KENVUE BRANDS LLC]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The mouthwash contains a combination of essential oils (eucalyptol, menthol, methyl salicylate, thymol) and alcohol that work as antimicrobial agents to disrupt bacterial cell membranes and inhibit microbial growth in the oral cavity. This reduces plaque accumulation, gingivitis, and bad breath by eliminating odor-causing bacteria.","oneSentence":"Listerine Cool Mint kills oral bacteria and reduces plaque formation through its essential oil and alcohol active ingredients.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:52:34.305Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Reduction of plaque and gingivitis"},{"name":"Bad breath control"},{"name":"General oral antisepsis"}]},"trialDetails":[{"nctId":"NCT04966507","phase":"PHASE2","title":"Antibacterial Mouthwash for Pharyngeal Gonorrhea Prevention","status":"COMPLETED","sponsor":"University of California, Los Angeles","startDate":"2022-02-17","conditions":"Gonorrhea","enrollment":89},{"nctId":"NCT05121909","phase":"PHASE4","title":"A Study of Experimental Mouthwashes","status":"COMPLETED","sponsor":"Johnson & Johnson Consumer Inc. (J&JCI)","startDate":"2021-11-15","conditions":"Gingivitis, Plaque","enrollment":274},{"nctId":"NCT05756673","phase":"PHASE4","title":"A Study of Virtually Supervised Mouthwash and Interdental Brushes","status":"COMPLETED","sponsor":"Johnson & Johnson Consumer Inc. (J&JCI)","startDate":"2023-02-09","conditions":"Healthy","enrollment":292},{"nctId":"NCT05645705","phase":"PHASE4","title":"A Two-Week Study of Clinical Safety and Saliva Flow Quantification","status":"COMPLETED","sponsor":"Johnson & Johnson Consumer Inc. (J&JCI)","startDate":"2022-11-28","conditions":"Healthy","enrollment":270},{"nctId":"NCT05526586","phase":"PHASE4","title":"A Twelve Week Study of Prototypes Mouth Rinses","status":"COMPLETED","sponsor":"Johnson & Johnson Consumer Inc. (J&JCI)","startDate":"2022-08-31","conditions":"Healthy","enrollment":192},{"nctId":"NCT05600231","phase":"PHASE4","title":"A Study of Virtually Supervised Mouth Rinses and Flossing","status":"COMPLETED","sponsor":"Johnson & Johnson Consumer Inc. (J&JCI)","startDate":"2022-04-18","conditions":"Healthy","enrollment":284},{"nctId":"NCT04750005","phase":"PHASE4","title":"A Twelve Week Study of Virtually Supervised Mouth Rinse and Flossing","status":"COMPLETED","sponsor":"Johnson & Johnson Consumer Inc. (J&JCI)","startDate":"2020-10-23","conditions":"Healthy","enrollment":209},{"nctId":"NCT02233998","phase":"NA","title":"A Clinical Trial to Test the Effect of Marketed Mouth Rinses on Decreasing Plaque and Gum Inflammation","status":"COMPLETED","sponsor":"Johnson & Johnson Consumer and Personal Products Worldwide","startDate":"2014-08","conditions":"Plaque, Gingivitis","enrollment":158}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"LISTERINE COOL MINT Antiseptic Mouthwash","genericName":"LISTERINE COOL MINT Antiseptic Mouthwash","companyName":"Johnson & Johnson Consumer Inc. (J&JCI)","companyId":"johnson-johnson-consumer-inc-j-jci","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Listerine Cool Mint kills oral bacteria and reduces plaque formation through its essential oil and alcohol active ingredients. Used for Reduction of plaque and gingivitis, Bad breath control, General oral antisepsis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}