{"id":"liposomal-bupivacaine-left-injection","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site pain or discomfort"},{"rate":null,"effect":"Transient neurological symptoms"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Systemic toxicity (rare)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Bupivacaine, an amide-type local anesthetic, works by inhibiting sodium influx through sodium-selective channels in the nerve cell membrane, thereby preventing depolarization and blocking pain signal transmission. The liposomal formulation encapsulates bupivacaine in lipid vesicles, which extends the drug's duration of action and allows for prolonged local anesthesia at the injection site. This formulation reduces systemic toxicity while maintaining efficacy for regional anesthesia.","oneSentence":"Liposomal bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses to produce local anesthesia.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:52:34.763Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Local anesthesia for infiltration, nerve block, and regional anesthesia procedures"}]},"trialDetails":[{"nctId":"NCT05374499","phase":"PHASE4","title":"Double-Blinded Randomized Controlled Study Investigating the Efficacy of Exparel (Liposomal Bupivacaine) for Postoperative Pain Relief in Mandibular Third Molar Extractions","status":"COMPLETED","sponsor":"University of Southern California","startDate":"2022-09-01","conditions":"Post Operative Pain","enrollment":73},{"nctId":"NCT04680221","phase":"PHASE4","title":"Stopping Opioid Overuse in Obstetrics to Halt Exposure Trial","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Missouri, Kansas City","startDate":"2021-03-01","conditions":"Pain, Postoperative, Opioid Use","enrollment":97},{"nctId":"NCT03305666","phase":"PHASE4","title":"Trial of Injected Liposomal Bupivacaine vs Bupivacaine Infusion After Surgical Stabilization of Rib Fractures","status":"COMPLETED","sponsor":"Denver Health and Hospital Authority","startDate":"2017-10-05","conditions":"Drug Effect, Rib Fractures, Rib Trauma","enrollment":36},{"nctId":"NCT01919190","phase":"PHASE4","title":"EXPAREL Administered by Infiltration Into the TAP for Prolonged Postsurgical Analgesia in Lower Abdominal Surgeries","status":"TERMINATED","sponsor":"Pacira Pharmaceuticals, Inc","startDate":"2013-08","conditions":"Pain","enrollment":67},{"nctId":"NCT01582477","phase":"PHASE4","title":"TAP-patients With Robotic Assisted Lap Prostatectomy","status":"COMPLETED","sponsor":"Pacira Pharmaceuticals, Inc","startDate":"2012-03","conditions":"Postsurgical Pain, Analgesia, Prostatectomy","enrollment":24},{"nctId":"NCT03420638","phase":"PHASE4","title":"EXPAREL Post-tonsillectomy Clinical Trial","status":"UNKNOWN","sponsor":"Paul Hoff","startDate":"2018-02-15","conditions":"Tonsillectomy","enrollment":38},{"nctId":"NCT03383198","phase":"PHASE4","title":"Pectoralis (II) Block With Liposomal Bupivacaine vs Bupivacaine for Breast Surgery","status":"TERMINATED","sponsor":"Prisma Health-Upstate","startDate":"2017-12-01","conditions":"Pain, Postoperative","enrollment":5},{"nctId":"NCT02197273","phase":"NA","title":"Liposomal Bupivacaine Versus Standard Analgesia in Total Joint Arthroplasty (TJA)","status":"COMPLETED","sponsor":"OhioHealth","startDate":"2014-07","conditions":"Osteoarthritis, Knee, Osteoarthritis, Hip, Osteoarthritis, Shoulder","enrollment":211}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Exparel Left"],"phase":"marketed","status":"active","brandName":"Liposomal bupivacaine left injection","genericName":"Liposomal bupivacaine left injection","companyName":"Prisma Health-Upstate","companyId":"prisma-health-upstate","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Liposomal bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses to produce local anesthesia. Used for Local anesthesia for infiltration, nerve block, and regional anesthesia procedures.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}