{"id":"lipid-emulsion-for-tpn","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypertriglyceridemia"},{"rate":null,"effect":"Lipemia"},{"rate":null,"effect":"Phlebitis at infusion site"},{"rate":null,"effect":"Allergic reactions"},{"rate":null,"effect":"Hepatic steatosis with prolonged use"}]},"_chembl":{"chemblId":"CHEMBL3354642","moleculeType":"Small molecule","molecularWeight":"1826.45"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Lipid emulsions are oil-in-water emulsions containing triglycerides, phospholipids, and other lipid components that serve as a concentrated caloric source and supply essential fatty acids (linoleic and alpha-linolenic acid) required for cellular function and membrane synthesis. When administered intravenously as part of TPN, they bypass the gastrointestinal tract and provide direct nutritional support to patients with severe malabsorption, critical illness, or post-surgical conditions.","oneSentence":"Lipid emulsion provides essential fatty acids and calories as a component of total parenteral nutrition (TPN) for patients unable to eat or absorb nutrients orally.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:34:02.891Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Total parenteral nutrition (TPN) in patients unable to tolerate enteral feeding"},{"name":"Severe malabsorption or short bowel syndrome"},{"name":"Post-operative nutritional support"}]},"trialDetails":[{"nctId":"NCT04031508","phase":"PHASE2","title":"Effect of a Parenteral Emulsion With Omega3 on Neonates With PPHN and CDH","status":"ENROLLING_BY_INVITATION","sponsor":"Coordinación de Investigación en Salud, Mexico","startDate":"2019-08-12","conditions":"Pulmonary Hypertension of Newborn, Diaphragm Defect","enrollment":40},{"nctId":"NCT05788588","phase":"PHASE3","title":"A Phase Ⅲ Study of HR19006 Injection in Postsurgical Parenteral Nutrition","status":"UNKNOWN","sponsor":"Fujian Shengdi Pharmaceutical Co., Ltd.","startDate":"2023-04-28","conditions":"Parenteral Nutrition","enrollment":240},{"nctId":"NCT00826020","phase":"PHASE2","title":"Evaluation of Omegaven™ Parenteral Nutrition in Patients With Total Parenteral Nutrition (TPN)-Induced Cholestasis","status":"COMPLETED","sponsor":"University of Nebraska","startDate":"2009-05-01","conditions":"Parenteral Nutrition Associated Liver Disease PNALD, Cholestasis","enrollment":72},{"nctId":"NCT04025021","phase":"NA","title":"Targeted Breast Milk Fortification for Very Low Birth Weight Infants in the NICU","status":"TERMINATED","sponsor":"MetroHealth Medical Center","startDate":"2019-10-01","conditions":"Human Milk, Neonate, Breast Milk","enrollment":3},{"nctId":"NCT01369147","phase":"PHASE2","title":"The Energy Dose Study","status":"TERMINATED","sponsor":"Emory University","startDate":"2011-07","conditions":"Critical Illness","enrollment":12},{"nctId":"NCT01412359","phase":"","title":"Compassionate Use of Omegaven® in the Treatment of Parenteral Nutrition Associated Hepatic Injury","status":"APPROVED_FOR_MARKETING","sponsor":"Jeffrey Rudolph","startDate":"","conditions":"Total Parenteral Nutrition-induced Cholestasis","enrollment":""},{"nctId":"NCT02010034","phase":"NA","title":"Compassionate Use of Omegaven in the Treatment of Parenteral Nutrition Induced Hepatic Injury","status":"COMPLETED","sponsor":"Children's Medical Center Dallas","startDate":"2013-08","conditions":"Liver Disease, Impaired Liver Function, Parenteral Nutrition Associated Liver Disease","enrollment":15},{"nctId":"NCT00672854","phase":"PHASE2, PHASE3","title":"Study Comparing a Soybean Oil-Based With an Olive Oil-Based Lipid Emulsion in ICU Patients Requiring TPN","status":"COMPLETED","sponsor":"Emory University","startDate":"2008-11","conditions":"Parenteral Nutrition","enrollment":100},{"nctId":"NCT01565278","phase":"PHASE3","title":"Fish Oil for Patients With Liver Disease Due to Parenteral Nutrition","status":"TERMINATED","sponsor":"Johane Allard","startDate":"2012-02","conditions":"Total Parenteral Nutrition-induced Cholestasis","enrollment":2},{"nctId":"NCT00989339","phase":"PHASE2, PHASE3","title":"Effects of Intralipid Versus Olive Oil Infusions on Endothelial Function, Immune Function, Inflammatory Markers","status":"WITHDRAWN","sponsor":"Emory University","startDate":"2009-11","conditions":"Diabetes, Hypertension, Obesity","enrollment":""},{"nctId":"NCT00396461","phase":"PHASE4","title":"ICULIP, Influence of Two Lipid Emulsions in the Nosocomial Infection in Critical Patients","status":"TERMINATED","sponsor":"B. Braun Medical SA","startDate":"2006-11","conditions":"Critical Illness","enrollment":212},{"nctId":"NCT00885781","phase":"PHASE4","title":"Efficacy and Safety Comparison Between SMOFlipid and Lipovenoes MCT","status":"COMPLETED","sponsor":"National Taiwan University Hospital","startDate":"2008-11","conditions":"Gastrectomy, Malnutrition","enrollment":40}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":379,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["SMOFlipid 20%"],"phase":"marketed","status":"active","brandName":"lipid emulsion for TPN","genericName":"lipid emulsion for TPN","companyName":"National Taiwan University Hospital","companyId":"national-taiwan-university-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Lipid emulsion provides essential fatty acids and calories as a component of total parenteral nutrition (TPN) for patients unable to eat or absorb nutrients orally. Used for Total parenteral nutrition (TPN) in patients unable to tolerate enteral feeding, Severe malabsorption or short bowel syndrome, Post-operative nutritional support.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}