{"id":"linopirdine","rwe":[{"pmid":"41567365","year":"2026","title":"Pan-cancer gene signature analysis of macrophage polarization and compound prediction for reprogramming tumor-associated macrophages toward M1-like macrophages.","finding":"","journal":"Cancer pathogenesis and therapy","studyType":"Clinical Study"},{"pmid":"40813301","year":"2026","title":"The Second-Generation Antipsychotic Perospirone Inhibits Voltage-Gated K(+) Channels in Coronary Arterial Smooth Muscle Cells.","finding":"","journal":"Journal of applied toxicology : JAT","studyType":"Clinical Study"},{"pmid":"40272900","year":"2025","title":"In vitro seizure risk assessment using a microelectrode array and comparison with an in vivo rat study.","finding":"","journal":"Toxicological sciences : an official journal of the Society of Toxicology","studyType":"Clinical Study"},{"pmid":"39961913","year":"2025","title":"Drug repositioning based on mutual information for the treatment of Alzheimer's disease patients.","finding":"","journal":"Medical & biological engineering & computing","studyType":"Clinical Study"},{"pmid":"39653067","year":"2025","title":"Blockade of Voltage-Gated K(+) Channels in Rabbit Coronary Arterial Smooth Muscle Cells by the Antipsychotic Drug Zotepine.","finding":"","journal":"Journal of applied toxicology : JAT","studyType":"Clinical Study"}],"tags":[{"label":"linopirdine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Potassium voltage-gated channel subfamily KQT member 2","category":"target"},{"label":"KCNQ2","category":"gene"},{"label":"KCNQ4","category":"gene"},{"label":"KCNQ5","category":"gene"},{"label":"N06BX09","category":"atc"},{"label":"Active","category":"status"},{"label":"Cardiovascular Agents","category":"pharmacology"},{"label":"Central Nervous System Agents","category":"pharmacology"},{"label":"Membrane Transport Modulators","category":"pharmacology"},{"label":"Neuroprotective Agents","category":"pharmacology"},{"label":"Potassium Channel Blockers","category":"pharmacology"},{"label":"Protective Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["linopirdine"],"offLabel":[],"synonyms":["linopirdine"],"timeline":[],"approvals":[],"ecosystem":[],"mechanism":{"target":"Potassium voltage-gated channel subfamily KQT member 2, Potassium voltage-gated channel subfamily KQT member 4, Potassium voltage-gated channel subfamily KQT member 5","targets":[{"gene":"KCNQ2","source":"DrugCentral","target":"Potassium voltage-gated channel subfamily KQT member 2","protein":"Potassium voltage-gated channel subfamily KQT member 2"},{"gene":"KCNQ4","source":"DrugCentral","target":"Potassium voltage-gated channel subfamily KQT member 4","protein":"Potassium voltage-gated channel subfamily KQT member 4"},{"gene":"KCNQ5","source":"DrugCentral","target":"Potassium voltage-gated channel subfamily KQT member 5","protein":"Potassium voltage-gated channel subfamily KQT member 5"}],"modality":"Small Molecule","drugClass":"linopirdine","explanation":"Think of your brain as a city with many roads. Potassium channels are like traffic lights that control the flow of traffic. LinoPIRDINE acts like a traffic cop, blocking the traffic lights to slow down the flow of electrical signals in the brain.","oneSentence":"LinoPIRDINE works by blocking potassium channels in the brain, which helps to regulate the flow of electrical signals.","technicalDetail":"LinoPIRDINE selectively blocks the Kv7.2 potassium channel, a member of the voltage-gated potassium channel subfamily KQT, which plays a critical role in regulating neuronal excitability and synaptic transmission."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4588","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=LINOPIRDINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T12:22:03.990340","biosimilars":[],"competitors":[{"drugName":"dronedarone","drugSlug":"dronedarone","fdaApproval":"2009-07-01","patentExpiry":"Jun 30, 2031","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"pyrithione zinc","drugSlug":"pyrithione-zinc","fdaApproval":"","patentStatus":"Unknown","relationship":"same-target"},{"drugName":"retigabine","drugSlug":"retigabine","fdaApproval":"2011-06-10","relationship":"same-target"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"linopirdine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"dronedarone","brandName":"dronedarone","genericName":"dronedarone","approvalYear":"2009","relationship":"same-target"},{"drugId":"pyrithione-zinc","brandName":"pyrithione zinc","genericName":"pyrithione zinc","approvalYear":"","relationship":"same-target"},{"drugId":"retigabine","brandName":"retigabine","genericName":"retigabine","approvalYear":"2011","relationship":"same-target"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"UNII":"I5TB3NZ94T","CHEBI":"CHEBI:34823","INN_ID":"6952","UMLSCUI":"C0286263","ChEMBL_ID":"CHEMBL319111","KEGG_DRUG":"D04741","DRUGBANK_ID":"DB13806","PDB_CHEM_ID":" FCC","PUBCHEM_CID":"3932","IUPHAR_LIGAND_ID":"2599","MESH_SUPPLEMENTAL_RECORD_UI":"C061017"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":216,"therapeuticAreas":["Neuroscience"],"atcClassification":{"source":"DrugCentral","atcCode":"N06BX09","allCodes":["N06BX09"]},"biosimilarFilings":[],"recentPublications":[{"date":"2026 Mar","pmid":"41567365","title":"Pan-cancer gene signature analysis of macrophage polarization and compound prediction for reprogramming tumor-associated macrophages toward M1-like macrophages.","journal":"Cancer pathogenesis and therapy"},{"date":"2026 Jan","pmid":"40813301","title":"The Second-Generation Antipsychotic Perospirone Inhibits Voltage-Gated K(+) Channels in Coronary Arterial Smooth Muscle Cells.","journal":"Journal of applied toxicology : JAT"},{"date":"2025 Jul 1","pmid":"40272900","title":"In vitro seizure risk assessment using a microelectrode array and comparison with an in vivo rat study.","journal":"Toxicological sciences : an official journal of the Society of Toxicology"},{"date":"2025 Aug","pmid":"39961913","title":"Drug repositioning based on mutual information for the treatment of Alzheimer's disease patients.","journal":"Medical & biological engineering & computing"},{"date":"2025 Apr","pmid":"39653067","title":"Blockade of Voltage-Gated K(+) Channels in Rabbit Coronary Arterial Smooth Muscle Cells by the Antipsychotic Drug Zotepine.","journal":"Journal of applied toxicology : JAT"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"LINOPIRDINE","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Linopiridine is a small molecule with the synonyms DUP 996, DUP-996, Lino piridina, Lino piridine, and Lino piridine.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}