{"id":"linaclotide-72-micrograms","safety":{"commonSideEffects":[{"rate":"20","effect":"Diarrhea"},{"rate":"12","effect":"Abdominal pain"},{"rate":"8","effect":"Abdominal distension"},{"rate":"7","effect":"Nausea"},{"rate":"6","effect":"Headache"}]},"_chembl":{"chemblId":"CHEMBL3301675","moleculeType":"Protein","molecularWeight":"1526.77"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"By activating GC-C receptors on the apical surface of intestinal epithelial cells, linaclotide increases cGMP levels, which opens cystic fibrosis transmembrane conductance regulator (CFTR) chloride channels and promotes water secretion into the intestinal lumen. This increases stool frequency and softens stool consistency, providing relief from constipation and associated abdominal discomfort.","oneSentence":"Linaclotide is a guanylate cyclase-C (GC-C) agonist that increases intracellular cyclic GMP in intestinal epithelial cells, promoting fluid secretion and accelerating intestinal transit.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:34:01.564Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chronic idiopathic constipation"},{"name":"Irritable bowel syndrome with constipation (IBS-C)"}]},"trialDetails":[],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Linaclotide 72 micrograms","genericName":"Linaclotide 72 micrograms","companyName":"Md Mehedi Shahriar","companyId":"md-mehedi-shahriar","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Linaclotide is a guanylate cyclase-C (GC-C) agonist that increases intracellular cyclic GMP in intestinal epithelial cells, promoting fluid secretion and accelerating intestinal transit. Used for Chronic idiopathic constipation, Irritable bowel syndrome with constipation (IBS-C).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}