{"id":"lidoderm-5-topical-patch","safety":{"commonSideEffects":[{"rate":"5-10","effect":"Skin irritation or erythema at application site"},{"rate":"1-5","effect":"Dermatitis or allergic contact dermatitis"},{"rate":"1-3","effect":"Localized edema"}]},"_chembl":{"chemblId":"CHEMBL2108694","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Lidocaine is a local anesthetic that penetrates the skin and reversibly inhibits sodium influx in nerve membranes, preventing depolarization and conduction of pain impulses. The 5% patch formulation delivers lidocaine transdermally to provide localized analgesia without systemic absorption. This mechanism allows sustained pain relief in the area of application for up to 12 hours.","oneSentence":"Lidocaine blocks sodium channels in nerve fibers, interrupting pain signal transmission when applied topically to the skin.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:52:18.242Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Postherpetic neuralgia (localized neuropathic pain)"},{"name":"Localized pain relief"}]},"trialDetails":[{"nctId":"NCT07060976","phase":"NA","title":"To Check Dermatological Safety of Test Products by 24 Hours Patch Testing","status":"COMPLETED","sponsor":"Novamed Laboratories Pvt. 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Dermatosis","enrollment":48},{"nctId":"NCT01509729","phase":"NA","title":"Topical Lidocaine After Major Arthroscopic Knee Surgery","status":"COMPLETED","sponsor":"Northern Orthopaedic Division, Denmark","startDate":"2011-06","conditions":"Fracture of Patella, Pain","enrollment":21},{"nctId":"NCT00904111","phase":"PHASE2","title":"A Study Comparing The Efficacy And Safety Of Lidocaine 5% Patch With Placebo In Patients With Chronic Axial Low Back Pain","status":"COMPLETED","sponsor":"Endo Pharmaceuticals","startDate":"2004-08","conditions":"Chronic Low Back Pain","enrollment":215},{"nctId":"NCT01494311","phase":"PHASE4","title":"Rapydan Topical Anaesthesia for Arterial Cannulation","status":"COMPLETED","sponsor":"Medical University of Vienna","startDate":"2011-03","conditions":"Arterial Catheterization","enrollment":90},{"nctId":"NCT01112748","phase":"PHASE4","title":"Topical Lidocaine: Predictors of Response in Peripheral Nerve Injury","status":"COMPLETED","sponsor":"Danish Pain 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