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This dual-agent formulation is designed to provide faster onset and more effective topical anesthesia compared to single-agent products.","oneSentence":"Lidocaine and tetracaine are local anesthetics that block sodium channels in nerve fibers, preventing pain signal transmission at the site of application.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:52:13.523Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Topical anesthesia for minor surgical procedures"},{"name":"Dermatological procedures requiring local anesthesia"}]},"trialDetails":[{"nctId":"NCT03342079","phase":"NA","title":"Effectiveness of Nitrous Oxide 50% for Reducing Pain and Distress Associated with Needle-stick in Children","status":"WITHDRAWN","sponsor":"Boston Children's Hospital","startDate":"2014-03","conditions":"Local Anesthetic Efficacy","enrollment":""},{"nctId":"NCT02996097","phase":"NA","title":"Fractional Laser Assisted Steroid Therapy vs Intralesional Steroids in the Treatment of Keloids","status":"COMPLETED","sponsor":"Johns Hopkins University","startDate":"2016-04","conditions":"Keloid","enrollment":30},{"nctId":"NCT01744197","phase":"PHASE2","title":"Synera Venipuncture Pain","status":"COMPLETED","sponsor":"US Oncology Research","startDate":"2013-01","conditions":"Pain, Phlebotomy, Palliative Care","enrollment":61},{"nctId":"NCT00530803","phase":"PHASE2","title":"The Efficacy of EMLA Cream vs. Synera Patch for Pain Reduction During Venipuncture in Children","status":"COMPLETED","sponsor":"Montefiore Medical Center","startDate":"2007-06","conditions":"Pain, Needle Phobia","enrollment":100},{"nctId":"NCT01834586","phase":"PHASE4","title":"Anesthetic Topical Adhesive (Synera™) to Reduce Injection Pain With Subcutaneous Multiple Sclerosis Medications","status":"COMPLETED","sponsor":"Brown, Theodore R., M.D., MPH","startDate":"2013-03","conditions":"Multiple Sclerosis","enrollment":30},{"nctId":"NCT01623583","phase":"PHASE4","title":"Effect of Including Synera® in Discussions on Dialysis Access Conversion in Patients With Needle Phobias","status":"TERMINATED","sponsor":"Davita Clinical Research","startDate":"2014-04","conditions":"Needle Phobia, Phobic Disorders","enrollment":10},{"nctId":"NCT02240628","phase":"PHASE4","title":"Combining Placing a Synera Patch With Propofol/Lidocaine Mixture to Decrease Pain With IV Propofol Injection","status":"COMPLETED","sponsor":"The University of Texas Health Science Center, Houston","startDate":"2014-08","conditions":"Pain on IV Injection of Propofol.","enrollment":76},{"nctId":"NCT02519660","phase":"PHASE3","title":"Needle Procedures Success Rate After Application of Ralydan vs EMLA in Children","status":"COMPLETED","sponsor":"IRCCS Burlo Garofolo","startDate":"2015-04","conditions":"Procedural Pain Relief","enrollment":339},{"nctId":"NCT01775605","phase":"PHASE4","title":"Study of Use of Synera for Pain During Local Skin Infiltration With Lidocaine Before Epidural Placement","status":"WITHDRAWN","sponsor":"Northwell Health","startDate":"2013-11","conditions":"Pain, Anxiety","enrollment":""},{"nctId":"NCT01654302","phase":"PHASE1, PHASE2","title":"Efficacy and Safety of Synera in Osteoarthritis Pain","status":"COMPLETED","sponsor":"Thomas J. 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Used for Topical anesthesia for minor surgical procedures, Dermatological procedures requiring local anesthesia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}