{"id":"lidocaine-esmolol-combo","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Injection site reactions"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Nausea"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This combination uses lidocaine's local anesthetic properties to numb tissue by inhibiting sodium influx in nerve cells, preventing pain signal transmission. Esmolol acts as a short-acting beta-blocker that selectively antagonizes beta-1 adrenergic receptors on cardiac tissue, reducing heart rate, contractility, and blood pressure. Together, they provide anesthesia with hemodynamic control, commonly used during anesthesia induction and intubation procedures.","oneSentence":"Lidocaine blocks sodium channels to provide local anesthesia, while esmolol is a beta-1 selective adrenergic antagonist that reduces heart rate and blood pressure.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:52:14.762Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Anesthesia induction and maintenance with hemodynamic control"},{"name":"Prevention of hypertensive response during intubation"}]},"trialDetails":[{"nctId":"NCT01114997","phase":"PHASE4","title":"Effect of Lidocaine and Esmolol to Improve the Quality of Recovery","status":"TERMINATED","sponsor":"Cedars-Sinai Medical Center","startDate":"2010-04","conditions":"Pain, Constipation, Nausea","enrollment":32}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Lidocaine + Esmolol (Combo)","genericName":"Lidocaine + Esmolol (Combo)","companyName":"Cedars-Sinai Medical Center","companyId":"cedars-sinai-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Lidocaine blocks sodium channels to provide local anesthesia, while esmolol is a beta-1 selective adrenergic antagonist that reduces heart rate and blood pressure. Used for Perioperative hemodynamic management and local anesthesia during surgical procedures.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}