{"id":"licensed-spikevax-vaccine","safety":{"commonSideEffects":[{"rate":"~70%","effect":"Injection site pain"},{"rate":"~60%","effect":"Fatigue"},{"rate":"~55%","effect":"Headache"},{"rate":"~40%","effect":"Myalgia"},{"rate":"~35%","effect":"Chills"},{"rate":"~15%","effect":"Fever"},{"rate":"~10%","effect":"Lymphadenopathy"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The vaccine contains lipid nanoparticles encapsulating messenger RNA encoding the spike protein of SARS-CoV-2. Upon intramuscular injection, the mRNA is taken up by host cells, which translate it to produce spike protein antigen. This stimulates both CD8+ T-cell and B-cell adaptive immune responses, generating neutralizing antibodies and cellular immunity against the virus.","oneSentence":"Spikevax is an mRNA vaccine that instructs cells to produce the SARS-CoV-2 spike protein, triggering an immune response to protect against COVID-19 infection.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:19:01.306Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of COVID-19 disease caused by SARS-CoV-2 virus (primary series and booster doses)"}]},"trialDetails":[{"nctId":"NCT06354998","phase":"PHASE3","title":"A Study of an Investigational mRNA-1273.815 COVID-19 Vaccine in Previously Vaccinated Adults","status":"COMPLETED","sponsor":"ModernaTX, Inc.","startDate":"2024-04-08","conditions":"SARS-CoV-2","enrollment":217}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Licensed Spikevax Vaccine","genericName":"Licensed Spikevax Vaccine","companyName":"ModernaTX, Inc.","companyId":"modernatx-inc","modality":"Biologic","firstApprovalDate":"","aiSummary":"Spikevax is an mRNA vaccine that instructs cells to produce the SARS-CoV-2 spike protein, triggering an immune response to protect against COVID-19 infection. Used for Prevention of COVID-19 disease caused by SARS-CoV-2 virus (primary series and booster doses).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}