{"id":"libexin","safety":{"commonSideEffects":[{"rate":null,"effect":"Drowsiness"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Headache"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Libexin (prenoxdiazine) works through a combination of local anesthetic effects on the airways and central cough suppression without opioid activity. It reduces the sensitivity of cough receptors in the respiratory tract, thereby decreasing the cough reflex while maintaining normal airway clearance and respiratory function.","oneSentence":"Libexin is a non-narcotic antitussive agent that suppresses cough by acting as a local anesthetic on the respiratory mucosa and reducing airway irritation.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:49:29.031Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Dry cough and unproductive cough in various respiratory conditions"}]},"trialDetails":[{"nctId":"NCT03837938","phase":"PHASE3","title":"Clinical Trial of Efficacy and Safety of Levopront® 30 mg/5 ml in Patients With Dry Cough","status":"COMPLETED","sponsor":"Dompé Farmaceutici S.p.A","startDate":"2016-11-09","conditions":"Cough","enrollment":184}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["prenoxdiazine"],"phase":"phase_3","status":"active","brandName":"Libexin®","genericName":"Libexin®","companyName":"Dompé Farmaceutici S.p.A","companyId":"domp-farmaceutici-s-p-a","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Libexin is a non-narcotic antitussive agent that suppresses cough by acting as a local anesthetic on the respiratory mucosa and reducing airway irritation. Used for Dry cough and unproductive cough in various respiratory conditions.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}